Why do man with high testosterone level would have low testosterone symptoms

Normal testosterone levels are between 264 and 916ng/dL, while some men with high testosterone level around 1000ng/dL still have low testosterone symptoms, including severe fatigue, slow recovery from exercise, libido problems, mild ED, depression, anxiety, and even reduced erections in the morning. Today we talk about possible causes.

Production and form of testosterone

The hypothalamic-pituitary-testicular axis (HPTA) controls the release of testosterone. After testis release the testosterone , this part of testosterone does not enter the blood circulation directly, but part of it bind to SHBG (sex hormone binding globulin), part of it bind to albumin, and only a small part (about 2%) unbind and can bind freely to androgen receptors. To make a difference. Therefore, this part of the unbound state of testosterone is Free T. The higher the level of Free T, the more benefits of high testosterone levels.

In addition to Free T, a portion of testosterone binds to albumin. Albumin is a carrier protein that has a low binding force with testosterone and can easily separate from the bind testosterone. This testosterone, which binds to albumin, arrive various parts of the body in the blood circulation. And then when testosterone separate from albumin, it also acts as testosterone.

The part of testosterone that binds to SHBG is difficult to separate from SHBG because it has a high affinity with SHBG. Therefore, this part of testosterone is equivalent to being wasted, unable to produce corresponding effects.

Conclusion

So, Free T is the most potent testosterone, followed by albumin bound testosterone, and finally SHBG bound testosterone. When we take a blood test, the total testosterone measured includes the part of the testosterone that is bound to SHBG, so when the total testosterone level is high, it does not mean that the body has a high level of available testosterone.

When you have a high testosterone level and, at the same time, a high SHBG level, then you are still likely to have low testosterone symptoms.

Boron helps reduce SHBG levels. There is also Proviron, a weak anabolic steroid that preferentially binds to SHBG, increasing the level of free testosterone and improving the utilization of testosterone and other AAS.