Why AAS using could damage liver?

Liver injury is an inevitable problem during the use of AAS. Many AAS have certain effects on the liver. Then, how does AAS damage the liver?

The most common tissue injuries of the liver are vascular congestion, degeneration, inflammation of the liver tissue, increased cytoplasmic fat vacuoles, resulting in liver deformity and sclerosis, thereby destroying the liver tissue and replacing it with connective tissue. The resulting fiber chains connect the liver region and create bridging fibrosis. With fibrosis and parenchymal injury, the normal structure of the liver will be destroyed and eventually cirrhosis will develop.

How does AAS use damage the liver?

Since the liver is a major site of steroid metabolism, it may be susceptible to AAS. However, it is not clear how AAS damage the liver. Studies have shown that AAS can affect liver health in the following ways.

1. ALT (alanine aminotransferase) and AST (aspartate aminotransferase) levels were above the normal range in individuals using AAS, and were close to the normal range after 12 weeks of disuse of these substances. That is, elevated ALT and AST levels affect liver health, but this effect is reversible.
2. Use of AAS interferes with the normal cycle of testosterone production in the body (i.e. inhibits endogenous testosterone production). By inhibiting testosterone production, blood cholesterol is no longer converted to pregnenolone, which raises blood cholesterol. It’s one of the factors that causes fatty liver disease. So some AAS use increases the risk of fatty liver disease.
3. The presence of ethyl or methyl groups in the drug structure of some AAS is usually the C17 position of the chemical structure of the added compound, which makes the AAS toxic to the liver and thus affects the liver health, and may be one of the important reasons for the elevated liver enzyme level in the blood. Therefore, bodybuilder can choose an AAS based on its chemical structure to determine whether the compound is bad for the liver, thus avoiding this AASOr use drugs to protect your liver.

Although the adverse effects of AAS on liver enzymes are significantly reduced over time, the dose and cycle length of AAS use appear to be important factors in the initiation of liver injury. Thus, bodybuilder can arrange the AAS cycle and dosage appropriately after learning about the liver damage that using AAS could cause.