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Some sarms, such as gw501516 and sr9009, we believe do not inhibit endogenous testosterone secretion and therefore do not need to use SERM clomiphene or enclomiphene. Other sarms, such as mk2866 and rad 140, mimic the mode of action of testosterone and inhibit endogenous testosterone production, requiring the use of SERM. Regarding when to use SERM, is it at the beginning of the cycle, in the middle of the cycle, near the end of the cycle junction, or after the cycle (PCT)? Different people have different opinions, and we have summarized these opinions.
We have talked a lot about the use of SERM after cycle (PCT), and if SERM is used during the period, sarms users prefer to use enclomiphene rather than clomiphene. In fact, in pct, they also use enclo. Today, we will not talk about the difference between enclo and clomid, but about which phase in the cycle they use serm.
A large percentage of bodybuilders prefer to use a SERM enclo on the first day of the cycle. They believe that sarms (mentioned here are inhibitory Sarms such as rad140, not non-inhibitory Sarms such as gw501516) mimic the action of testosterone, and it will start to exert inhibitory effects from the moment it enters the body, so you need to use serm enclo to maintain your endogenous testosterone secretion levels.
In terms of inhibition, the idea is correct. Doing so keeps endogenous testosterone levels uninhibited and at normal levels.
Bodybuilders, who hold this view, believe that with stronger sarms like RAD140, which have a very high inhibitory effect, there is a possibility of more severe testosterone inhibition or shutdown in the fourth week of the cycle, so it is necessary to start enclo earlier, preferably no later than the second week of the cycle.
Many people agree with this view, because for safety reasons, no one wants to have their testosterone levels severely suppressed or shut down. There is a dosing issue, rad140 dose is 10-30mg ED. Low doses of rad140 can be effective, and rad140 at low doses without severe testosterone suppression.
Some sarms start in the fourth week, with noticeable changes in muscle mass to strength levels, which is when hormone levels in the body maybe the highest, after which total testosterone levels begin to decline (inhibition begins to show). At this time, use SERM enclo to block the negative feedback effect of estrogen on HPTA, ensure the continuous release of testosterone, maintain testicular function, and maintain the testosterone level after the cycle.
Post-cycle therapy (PCT) is the official procedure for the sarms or AAS cycle. Compared with AAS, SARMs is safer and has fewer side effects, and basically does not have serious inhibitory effects when used in prescribed doses and prescribed cycles. Even in AAS cycles where inhibition is more severe, users tend to focus on getting gains in the cycle while addressing inhibition in the PCT. Because of the continued use of exogenous aas or sarms, the inhibitory effect will remain. This is equivalent to solving the problem while still suppressing it. Therefore, the inhibition effect brought by sarms can be solved in time after the cycle (pct), and it should be done.
Enclo maintains the release of testosterone by blocking the effect of estrogen on HPTA, except in the treatment of hypogonadism, in people with normal gonadism, use enclo at a low dose, EOD or E3D frequency, equivalent to intermittent use to stimulate HPTA without the need for long-term high dose use.
The use of enclo during the cycle blocks the brain’s response to estrogen, and even if excess estrogen in the body, it will not reflect through the body and will affect the accuracy of judging estrogen levels (reflected in bloodwork).
Why do many people use enclo at the beginning of a cycle, or during a cycle? This may be dose-related. They may have experienced side effects from high doses of the drug, so they prevent them in advance. Each sarms has its guiding dosage, the right dose to keep itself safe, rather than focusing on prevention.