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Metandienone is the first oral AAS, and the most popular oral AAS. It also known as methandienone, methandrostenolone, or dehydromethyl testosterone, is most commonly known as Dianabol. It was the first synthetic testosterone create by German scientists in 1935 and sell in Germany and the United States in 1955.
Metandienone was originally marketed as an androgen replacement therapy to treat male hypogonadism, and has since been used to treat postmenopausal osteoporosis and pituitary defect dwarfism, as well as recovery in burn patients.
It is a synthetic 17alpha-methylated AAS, and its structural changes allow it to pass through the liver without being broken down, making it an innovative way to use AAS compared to injectable AAS at the time. Oral AAS are more convenient, avoid the pain and risk of infection associated with injectable AAS, and offer a new way for those who resist needle injections to use them. It was of great significance at the time.
People develop AAS for purpose of increasing their anabolic activity and decreasing their androgen activity. Metandienone’s anabolic activity is 210% that of testosterone, with a higher synthetic metabolic activity than testosterone and moderate androgen activity. It allow bodybuilder to gain muscle with fewer androgen side effects during its use. So Metandienone is more effective than the same amount of testosterone, helping muscles grow faster.
As the first oral AAS, Metandienone is a derivative of testosterone, Aromatase may converte it into estrogen in the body. While other AAS later are mostly base on DHT, Aromatase couldn’t converte them into estrogen. When estrogen levels rise, it can lead to significant water retention and a risk of breast development in men. Therefore, It is necessary to pay attention to the level of estrogen in the body while using Metandienone. And add anti-estrogen (AI) when appropriate.
Because Metandienone is aromatized, there is a degree of water retention in the muscles gained from its use. Therefore, Bodybuilders mostly use it as a bulking AAS, while other oral AAS are mostly suitable for cutting.