What are your worst side effects on Retatrutide?

Retatrutide is a new experimental peptide, and many people are concerned about the side effects and long-term safety of Retatrutide compared to the approved peptides Semaglutide and Tirzepetide. Today we discuss the worst possible side effects of Retatrutide.

Retatrutide is a triple receptor agonist that acts on GLP-1R, GIPR and GCGR simultaneously, while Semaglutide acts on GLP-1R and Tirzpetide acts on GLP-1R and GIPR. Therefore, since trails verified the side effects and long-term safety of Semaglutide and Tirzepetide, we only need to understand the possible side effects of Retatrutide on GCGR.

Retatrutide acts on the benefits and possible side effects of GCGR

GCG is glucagon, also known as glucagon, its effect is the opposite of insulin. Retatrutide is based on GLP-1 and GIP, adding GCG, acting on GCGR can promote glycogen breakdown, converting stored glycogen into glucose, and then released into the blood to provide energy for the body. This mode of action enables Retatrutide to promote lipolysis and enhance fatty acid oxidation. Therefore, while helping to reduce fat, Reta converts fat into usable energy for the body, providing an energy source for skeletal muscle and other tissues, thereby improving the user’s exercise ability. This series of effects allows users to use Retatrutide without experiencing energy deficit such as exhaustion similar to Semaglutide or Trizepetide, and to have the energy to participate in exercise, further lose fat and retain muscle mass during exercise.

GCG is already FDA-approved for the treatment of severe hypoglycemia, and it also has some off-label uses. Corresponding to the above GCG benefits are the possible side effects of over-activation of the GCG receptor. Nausea is a common adverse side effect of GCG. Due to its protein structure, allergic reactions may occur with Retatrutide, including low blood pressure, rashes, and vomiting, but allergic reactions are rare at normal doses and more likely at higher doses.

In Retatrutide experiment, it has been found in a dose dependent makes the heart rate increased by 6.7 times per minute, this is likely to be harmful. At the same time, all those using GLP-1 receptor agonists as well as dual GLP-1/GIP receptor agonists observed an increase in heart rate compared to placebo, with an increase of approximately 2-6 beats per minute.  The increase in heart rate in patients using Retatrutide peaked at 24 weeks after starting treatment and partially declined thereafter.

Retatrutide worst side effects review

Compared to the more mature Semaglutide and Tirzepeptide, the possible side effects of Retatrutide are basically similar, except for allergies and effects on heart rate. The effect of Retatrutide on heart rate is generally of more concern, and from the clinical trials of Retatrutide, we can see that this is dose-dependent and slows down over time. In the dose design of Retatrutide, the lowest dose is 2mg/week, the highest dose is 12mg/week, and the strict titration of the dose will help reduce the occurrence of side effects.