What are selective androgen receptor modulators?

When someone asks, what is a SARM? We all know that SARM is a selective androgen receptor modulator.

So what are selective androgen receptor modulators?

Before we know what a selective androgen receptor modulator is, we need to understand the question “What is an androgen receptor?” “What is a regulator?” “What is selective?”

What are androgen receptors?

The main form of androgen is testosterone. Androgens play an important role in the body. In addition to reproduction, it can also maintain the balance of hormones in the body, stimulate protein anabolism, promote nitrogen deposition and increase the number and thickness of muscle fibers.

Androgens perform their functions by binding to androgen receptors.

The androgen receptor is a 120,000 Dalton molecular weight protein that is synthesized under the guidance of genes on the X chromosome. Androgen receptors are the intermediate substances in the action of androgens. Testosterone can only work by binding to androgen receptors. If there is no androgen receptor in the body, the androgen does not stimulate the tissue response. If androgen receptors are not sensitive, it will be difficult to build muscle.

Sensitivity to androgen receptors varies from person to person. Some people have large muscle size and low body fat, but their testosterone levels are actually not high in blood tests, probably because they have high androgen receptor levels. Some people train hard and eat well, but their muscles grow very slowly. A big reason for this is that the androgen receptors in the body are not sensitive.

Androgen receptor modulator (sarm) is designed to optimize this process and improve the efficiency of muscle synthesis.

What are receptor modulators?

In pharmacology, receptors are biomacromolecules composed of glycoproteins or lipoproteins that are present in the cell membrane, cytoplasm, or nucleus.

Receptor is a broad term in cell biology, referring to any biological macromolecule that can bind to hormones, neurotransmitters, drugs or signaling molecules within cells and cause changes in cell function.

Receptors are the components of cell membrane or cell that can recognize and bind to bioactive molecules, which can accurately amplify and transmit the signals recognized and received to the cell interior, thus causing biological effects.

When the receptor in the body is not sensitive, it will lead to the reduction of the binding rate with its ligand, can not achieve the corresponding effect. Receptor regulation can increase the sensitivity of the receptor and thus increase the probability of binding the receptor to its ligand.

Selective androgen receptor modulator (sarm) makes the androgen receptor more sensitive and can bind to more androgens, thus improving the efficiency of muscle synthesis.

What is selective?

Selective is the key word in selective androgen receptor modulators (sarm).

As bodybuilder increases the amount of androgens in the blood, it also adjusts the androgen receptors to bind to more androgens. At this time, if all the androgen receptors in the body are binding with androgens, the concentration of androgens is the highest in the prostate. A large number of androgens and androgen receptors are bound in the prostate, which will cause problems such as enlargement of the prostate. At the same time, androgen receptors in different parts of the body become sensitive and bind more to androgens, causing side effects such as acne and hair growth.

Selective androgen receptor modulators (SARMS) are selective and selectively bind to androgen receptors in bone and muscle to promote muscle growth and bone health without affecting the prostate and without a large number of androgen side effects.