Understand the benefits of IGF-1 from its medical value

The main purpose of IGF-1 used by Bodybuilders is to enhance anabolic action to build muscle, and in fact, IGF-1 has proven medical value for the treatment of a variety of diseases. We can also know IGF-1 benefits from its medical value.

Description of IGF-1

IGF-1, short for insulin-like growth factor 1, is very similar in molecular structure to insulin, primarily producing in the liver, and has anabolic effects in adults.

In addition to acting as IGF-1, IGF-1 supplementation stimulates endogenous IGF-1 production in the corresponding tissues. IGF-1 has a growth-promoting effect on almost every cell, especially benefits skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, etc. It promotes cell enlargement and division, inhibits apoptosis and increases cellular protein synthesis, coordinating the metabolism of proteins, carbohydrates and fats.

Treatment of primary IGF-1 deficiency with IGF-1 benefits

The FDA approved the use of rhIGF-1(also known as Mecasermin) for the treatment of severe primary IGF-1 deficiency in 2023. At the same time, the FDA approved the use of an equal molar combination of IGF-1 and IGFBP-3 (also known as Mecasermin Rinfabate) for the treatment of IGF-1 deficiency. Because IGFBP-3 also carries IGF-1, the carrier IGFBP-3 saturate with IGF-1 when administer IGF-1 alone, and IGF-2 can bypass to bind to IGF-1 when use an equimolar combination of IGF-1 and IGFBP-3 . We can use Both of these combine modes to treat growth disorders.

IGF-1 beneftis toTreat muscle injuries

The patented drug PEG-IGF-1 is an analogue of IGF-1, which provides effective protection against muscle damage caused by targeted acute contractions. Also use it to treat and prevent neuromuscular disorders, especially amyotrophic lateral sclerosis.

IGF-1 benefits for burns

In Phase II trials of IGF-1, the efficacy of IGF-1 in the treatment of severe burns in children was demonstrated and positive results were achieved at doses of 1-4mg/kg/day.

Use to treat osteopenia and osteoporosis

IGF-1 has been tested in patients with osteopenia and osteoporosis associated with anorexia nervosa and severe fractures at doses ranging from 30 µg to 1 mg/kg/ day for 2-9 months with positive results.

IGF-1 is a hormone that exists in almost all human tissues, mainly produce by GH stimulation, and it is also an autocrine hormone. In addition, supplementing exogenous IGF-1 can also stimulate the secretion of IGF-1 in body tissues.