To know Tamoxifen with its keywords

Tamoxifen, also known as Nolvadex, is a selective estrogen receptor modulator approved by the FDA to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer after surgery, or reduce the risk of breast cancer in high-risk women. In fact, Tamoxifen is so widely used in male bodybuilders that it acts as an anti-estrogen against the effects of estrogen on male breast development (gyno) and stimulates the re-secretion of suppressed endogenous testosterone in PCTS. Today, we mainly talk about the application of Tamoxifen in bodybuilding. Understand the following Tamoxifen keywords to help you use Tamoxifen better.

It competes with estrogen for estrogen receptors

As SERMs,Tamoxifen is highly selective. In the breast, Tamoxifen locks on to estrogen receptors, preventing estrogen from binding to them, and then estrogen cannot stimulate cell division and growth. This is the key reason why Tamoxifen treats estrogen receptor positive breast cancer, and the main reason why Tamoxifen treats gyno. Gyno occurs because large amounts of estrogen accumulate in the breast, binding to estrogen receptors in the breast and stimulating breast development. Tamoxifen blocks the binding of estrogen in the breast and prevents gyno production.

Stimulate the production of testosterone

Tamoxifen increases the secretion of luteinizing hormone LH and follicle hormone FSH through the antagonism of estrogen receptors, and thus the hormone testosterone produces testosterone. This is the main reason why Tamoxifen is used in PCTS. The main purpose of PCTS is to restore endogenous testosterone production, and Tamoxifen has this effect. Tamoxifen is one of the most commonly used PCT drugs.

It interacts with antiestrogen

Tamoxifen also acts as estrogen, interacting with some anti-estrogens. The aromatase inhibitor Arimidex induces the metabolism of Tamoxifen, while Tamoxifen induces the metabolism of the aromatase inhibitor Letrozole. Therefore, when bodybuilder uses Tamoxifen and needs to add AI, Arimidex and Letrozole should not be used. So which aromatase inhibitor should I choose? The Exemestan is available.

Mixed estrogen and antiestrogen activity

Tamoxifen acts as an anti-estrogen, which itself has estrogen effects. Its role varies from tissue to tissue. It has anti-estrogen effects in the breast and is therefore used to treat breast cancer and gyno. Estrogen acts in the uterus, liver and bones to prevent bone loss and prevent osteoporosis.

Tamoxifen keywords of Long half-life

Tamoxifen has a half-life of up to 14 days, and its metabolites are so active that they can stay in the body for months. So, with Tamoxifen, you don’t need to use very high doses. Because of its metabolite’s long half-life, Tamoxifen continues to function in the body even after disuse.