The Neuro nootropic Peptide Semax for cerebral stroke Parkinson neurological defects

Nootropic Semax, while developed based on the corticotropin 4-10 fragment (ACTH4-10), is a powerful neuro nootropic peptide drug. It was approved by the Government of the Russian Federation in 2011 as part of the list of important and essential medicines in Russia, mainly for the treatment of central nervous system diseases (including stroke, transient ischemic attack, optic nerve disease, etc.), memory and cognitive impairments, and the strengthening of the immune system.

While Natural regulatory peptides are usually bioactive compounds produce by various cells. They provide connections between the major regulatory systems of the body, are direct regulatory substances or mediators of most physiological processes occurring in the body, and have a wide range of preventive and therapeutic effects. By modifying the natural regulatory peptide, it can have higher stability, so that it better apply in medical treatment. Nootropic Semax is a synthetic analogue of natural regulatory peptides.

What is ACTH?

Adrenocorticotropin (ACTH) and its fragments are one of the most active endogenous regulatory peptides. ACTH is a single chain polypeptide compose of 39 amino acids, which form in the anterior pituitary gland through the translation and processing of the precursor proteinogen melanocortin (POMC).

ACTH is one of the major regulatory components of the pituitary-hypothalamic axis and interacts with the regulatory system of the hypothalamus. It can enhance the synthesis and secretion of glucocorticoid.

In addition to its hormonal effects, ACTH also exhibits a wide range of extra-hormonal activities

1. Multiple studies have shown that ACTH and its fragments can affect the behavior of human and animals. ACTH accelerates the learning process of animals, and it may directly act on the central nervous system without relying on the activity of ACTH hormone.
2. A large number of studies have shown that the N-terminal region of ACTH is the main region responsible for the behavioral activity of hormones, while ACTH4-10 is the smallest fragment that retains the behavioral effect of ACTH molecule.
3. ACTH and its fragments show neuroprotective and neurotrophic effects in addition to the role of puzzle. Studies have shown that even small doses of ACTH can stimulate the growth of nerve fibers.
4. Peripheral nerve regeneration induced by ACTH and ACTH4-10 fragments was accompanied by significant enhancement of neuronal RNA and protein synthesis.
5. ACTH also enhanced RNA and protein synthesis and glucose utilization in the brains of older animals.

What is Nootropic Peptide Semax?

Product name:Semax
Other name:Met-Glu-His-Phe-Pro-Gly-Pro
Cas:80714-61-0
MF:C 37 H 51 N 9 O 10 S
MW: 813.93
Purity :≥98%

The Origin of Nootropic Semax

The discovery of the remarkable intellectual, neuro protective, and neurotrophic effects of ACTH and its fragments makes this peptide one of the most promising candidates for the prevention and treatment of central nervous system diseases. However, these peptides are difficult to use in practice because of their extreme instability and short duration of action. The action time of ACTH4-10 is 30-60 min. After modification of different C-terminal, finding that the analogues carrying three C-terminal amino acids replace by Pro-Gly-Pro sequence show the longest activity. The peptide (h-met-glu-his-phi-pro-gly Pro-OH), is Semax, exhibits the intellectual-promoting effects of the natural prototype, while its action duration (Half-life) lasts 20-24 hours.

The Application of Nootropic Peptide Semax

In 2001, Nootropic Semax was developed to treat cerebral stroke. It has been shown to treat and prevent a wide range of diseases, including stroke, poor circulation encephalopathy, Parkinson’s disease, atrophy of the eyes, and a number of chronic conditions caused by insufficient blood circulation to the brain.

Semax has shown high efficacy in preventive enhancement of intelligence in healthy people under extreme stress conditions.

Nootropic Semax is also being developed to treat children with neurological defects (starting at age 3).

Peptide Nootropic Semax Benefits

Treatment of Cerebrovascular Diseases

Cerebrovascular diseases are a major cause of death worldwide, of which ischemic brain injury accounts for about 80%. Due to a severe decrease in blood flow in the brain, it causes a massive loss of neurons and leads to necrosis and penumbra formation. Experiments on the neuropeptide Semax have demonstrated strong neuroprotective effects.

Nootropic Semax Trials

1. Semax significantly reduced the number of damaged cells under oxidative stress conditions caused by hydrogen peroxide. Semax has antioxidant protection that protects the body and brain from various types of oxidative damage or stress.
2. Experiments on cultured embryonic rat brain cells showed that Semax could increase the number of viable neurons by 1.5-3.0 times compared with the control group, without affecting the proliferation of glial cells.
3. Semax significantly increased the survival of cerebellar granulosa neurons during glutamine (Gluta) neuropoisoning.
4. Semax increased the survival rate of cholinergic neurons in the basal forebrain by 1.5-1.7 times in vitro and stimulated acetylcholintransferase activity.
5. Studies on the antioxidant properties of the drug in rats have shown that at extreme altitudes (12000m), Semax increases the life span of the animal by 2.5 times and ADAPTS it to hypoxia.
6. Studies on the effects of Semax on acute hypoxia in rats of different ages show that a single Semax preconditioning can improve the individual resistance to hypoxia, positively influence cardiac function parameters during hypoxia, and reduce the behavioral changes caused by hypoxia.
7. Intraperitoneal injection of Semax can significantly improve the overall resistance to circulatory hypoxia and animal survival rate, and reduce the severity of neurological impairment.
8. A neuropsychological study showed that attention, memory, cognition, mobility, muscle function, and overall auditory memory improved after Semax treatment.

Clinically, Semax accelerates resolution of cerebral and focal abnormalities, facilitates intensive treatment and recovery from stroke, and reduces the risk of later stroke and ischemic attacks.

In addition to the treatment of brain diseases, visual impairment or blindness caused by partial or complete atrophy of the optic nerve, Semax benefits the quality and speed of recovery from treatment, helps improve visual function, and effectively protects optic nerve tissue from damage.

Relieve ADHD

Semax improves memory and increases lower neurotransmitters in people with ADHD. In Russia ,it is use as a common alternative to medication for children with ADHD. Since ADHD (Attention Deficit Hyperactivity Disorder) may be a neurodevelopmental condition.

Antianxiety Effect

Semax has antianxiety and antidepressant effects when anxiety and depression levels in normal people are increased by the administration of cholecystokinin tetrapeptide.

Semax also activates the dopaminergic and serotonergic systems that help prepare the brain for action and induce a controlled state of mental stress. It helps with depression and anxiety.

Help Relieve Pain

When the body feels pain, the brain releases enkephalins. These are neurotransmitters that reduce the sensation of pain.

This can also change the sensation of pain by reducing the sense of panic that can occur when the body feels pain.

Semax helps prevent the breakdown of enkephalins in the body. It can also increase the production of enkephalins. This helps to reduce the severity of the pain.

Improve Memory

Neurotransmitters like enkephalins affect perception. Thus, Semax can also increase the expression of memory.

Semax promotes neuronal survival in hypoxic conditions, increasing selective attention and memory storage. In the hippocampus, semax rapidly raises levels of BDNF (Brain-derived neurotrophic factor), an important protein that promotes the growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex and forebrain and is important for memory, coordination, attention and learning.

To Treat Alzheimer’s Disease

Alzheimer’s disease is the most common neurodegenerative disease. According to the World Alzheimer’s Report, more than 46.8 million people worldwide were affected by Alzheimer’s disease in 2015, and that number is expected to double in the next 20 years. The main hallmark of Alzheimer’s disease is the appearance of protein deposits inside neuron cells in the hippocampus region of the brain, called neurofibrillary tangles. In the extracellular space, called amyloid plaques, are made up mainly of fibrous aggregates of amyloid protein (Aβ). Semax prevents and treats Alzheimer’s disease by interfering with fibrillary formation to inhibit tangles.

In addition to the above benefits, the data suggest that healthy adults may be able to take Semax to prevent possible negative effects of their environment, especially long-term emotional stress. Semax also speeds up learning in animals, stops the development of cancerous tumors, helps healthy cells grow, and enhances immune cell activity.

Nootropic Semax Peptide Side Effects

Since the synthetic regulatory peptide analogs contain only natural amino acids in their composition, they do not lead to the formation of toxic products during their biodegradation, so the use of peptides has fewer side effects. There have been no reported side effects from Semax use.

Nootropic Semax Peptide Dose Half-life and Cycle

Semax has a half-life of 20-24 hours, so use it once a day. Others choose two or three times a day. Studies have shown that Semax begins to work as soon as 30 minutes after it enters the body.

It was originally developed as a nasal spray, and as the product has been researched and developed, the use of injections has become very widespread, however, it is believed that the bioavailability of nasal sprays is somewhat higher. Oral bioavailability of Semax is very low, so the oral form is not recommended.

Common doses of Semax range from 200mcg to 1mg, depending on the individual response of the user. It is advisable for novice users to take very small doses to test the body’s response to the substance, and novice users should always start with very low doses and gradually increase them. A common dose for users with some tolerance to peptides is 300-600mcg over a 4-8 week cycle.

Nootropic Semax’s Role in Bodybuilding

Semax stimulates the central nervous system. In addition to treating related diseases, improving memory, concentration, etc., it also increases energy and metabolism, and increases microcirculation in the body to improve overall performance. Semax also has stress level relief, anti-anxiety and anti-depressant and anti-inflammatory properties that help keep bodybuilder in good shape in bodybuilding.