Testosterone’s Dual Power: Unraveling its Role on Muscle Growth and Fat Reduction

If we don’t know exactly what testosterone does, we can easily name a few, including muscle growth aand fat reduction. If you ask how testosterone works, most people probably don’t know. Today, we will take a brief look at it.

What’s the use of that, you might say? Who knows, maybe one day you’ll need it, maybe someone just needs the knowledge.

The action of testosterone is through a combination of many different pathways, at the cellular and organ level, the action of testosterone does not depend on genomic mechanisms, most of the action is through the binding of hormone receptors. Bound androgen receptors act as transcriptional regulatory elements by binding to specific DNA response elements in target gene promoters, causing activation or inhibition of transcription and subsequent protein synthesis.

Testosterone Effects on muscle growth and strength

The effects of testosterone on muscle mass and strength occur primarily through binding to androgen receptors. The degree to which it works positively correlate with the dose, and if the dose is too low, it may not have any effect.

A study giving testosterone enanthate 200mg every 2 weeks found that an increase in mass was observed after 12 weeks, with the greatest effect achieved after 6-12 months. This is a very small dose at which improvements in muscle mass and strength are observed.

Effect on bone mineral density

The effect of testosterone on bone mineral density mediate by estrogen, which acts on testosterone derivatives produced after the interaction of testosterone with aromatase.

In the study, testosterone continued to improve lumbar bone mineral density from 6 months to 36 months.

Testosterone Effect on fat Reduction 

Testosterone plays an important role in obesity, glucose homeostasis and lipid metabolism. It promotes myogenic differentiation of mesenchymal pluripotent cells through androgen receptor-mediated pathway and inhibits their differentiation into fat. After using testosterone, fat mass will decrease and lean body mass will increase. There is no significant change in total weight at the beginning, and in general, total mass begins to increase after 3 months.

Testosterone induces changes in lipid metabolism and changes in insulin signaling after the receptors in the muscles as well as an increase in insulin sensitivity, resulting in a decrease in total cholesterol levels and triglyceride levels.

Except muscle growth ,fat reduction and bone health, Testosterone treatment also has a variety of effects such as lowering blood pressure, promoting cardiovascular health, reducing inflammation, and promoting sexual desire, affecting many parts of the body as well as physical and mental health.