Some sarms, such as gw501516 and sr9009, we believe do not inhibit endogenous testosterone secretion and therefore do not need to use SERM clomiphene or enclomiphene. Other sarms, such as mk2866 and rad 140, mimic the mode of action of testosterone and inhibit endogenous testosterone production, requiring the use of SERM. Regarding when to use SERM, is it at the …