SNAC, short for Salcaprozate sodium, is a major intestinal osmotic enhancer (PE) that can accompany poorly permeable macromolecules across the plasma membrane in a transcellular mode of action.  Thus, it is possible to increase oral absorption of several poorly permeable molecules that are jointly administered.   Up to now, SNAC is the most extensively tested vector and the only one approved …

Rybelsus (Main including Semaglutide and SNAC) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes on September 20, 2019.   Rybelsus, developed by A Danish pharmaceutical company and Nord Ag, is the first drug approved in the United States for glucagon-like peptide-1 (GLP-1) receptor protein that does not require an injection.   …

Chemical properties of SNAC:   SNAC is the short of Salcaprozate sodium   Molecular Formula:C15H20NNaO4 Molecular Weight:301.31 CAS:203787-91-1 The forms of SNAC:   We usually refer to the abbreviation SNAC as SNAC powder.  In addition to the powder state, there are SNAC crystal form, methanol-water cosolvent compound of SNAC and ethanol-water cosolvent compound of SNAC.   SNAC powder, also known as amorphous …

Since the discovery and isolation of insulin in the 1920s, more and more peptide products have been developed.  Unfortunately, most of the more than 60 approved peptide drugs and 150 peptides under active development are formulated as injections.  Oral peptides have been a consistent area of academic and industrial research.   However, two key challenges have hindered the development of oral peptides: …