Semaglutide is a long-term drug that requires lifetime use to maintain weight loss. Weight rebound in Semaglutide trials In the semaglutide trial, after 68 weeks of subcutaneous injection of Semaglutide 2.4mg or placebo combined with a lifestyle intervention, the Semaglutide group lost an average of 17.3% of body weight and the placebo group lost an average of 2% of body …