Neuroprotective PE22-28 is a peptide derive from the neuropeptide proopiomelanocortin (POMC), specifically from the sequence of the melanocortin receptor agonist alpha-melanocyte stimulating hormone (alpha-MSH). It has potential neuroprotective and anti-inflammatory effects, and also plays a role in mood, depression, and weight loss. How does PE22-28 work? PE22-28 works primarily by interacting with melanocortin receptors (mcr), a group of G-protein-coupled receptors …