Common side effects of oxymetholone include depression, drowsiness, headache, swelling, rapid weight gain, abnormal erections, altered skin color, nausea, loss of appetite, insomnia, and more. However, the main side effects of Oxymetholone are hepatotoxicity and hypertension. Toxicity to liver Oxymetholone is a C17-alpha-alkylated compound that protects it from inactivation through the liver. This gives Oxymetholone good oral activity, remaining active …