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The formation of the HPTA and the role of positive and negative feedback mechanisms

The formation of the HPTA and the role of positive and negative feedback mechanisms

All components of the hypothalamic-pituitary-testicular axis (HPTA) are established during fetal life, and its first activation occurs during the neonatal period, when circulating testosterone (mini puberty) reaches adult male levels for several months and produces androgenic imprinting in non-reproductive tissues. After a surge in the neonatal period, HPTA becomes stationary during the 10 years of childhood. Studies have shown that …

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