AMPK was officially named for the first time in 1988 in a paper published in the European Journal of Biochemistry.  Because of AMPK’s role in cell function, the study of AMPK agonists is extremely important.   However, developing a drug that can directly activate AMPK and have a therapeutic effect has been a challenge.  The development of AMPK direct agonists initially focused …

AICAR, short for 5-aminoimidazole-4-methamide-1-molar D-ribofuranoside, also known as AICARiboside or Acadesine,  is a kind of activated agent that permeates cell membrane AMP-activated protein kinase(AMPK) .   AMPK is a key protein in metabolic regulation, which can regulate cell energy and control cell metabolism.   AICAR is a recognized AMPK activator that plays an important role in the medical field. How does …