Tamoxifen has played an important role in various fields since it was discovered and approved for the treatment of breast cancer in 1970.
Tamoxifen is a selective estrogen receptor agonist (SERM) that selectively binds to estrogen receptors in the breast to inhibit breast estrogen levels and prevent breast cancer cells from using estrogen to grow and disperse. At the same time in bone and uterus show excitatory properties, in bones, play the role of estrogen agonist, can prevent osteoporosis, improve bone condition, in the hypothalamus and uterus act as estrogen agonist, thereby promoting gonadal hormone levels.
Tamoxifen to treat breast cancer
That’s the original role of Tamoxifen. Tamoxifen selectively binds to estrogen receptors in breast cancer cells and works by preventing cancer cells from getting the hormones they need to reproduce and grow.
It’s not just women who are at risk for breast cancer, it’s also men, and Tamoxifen is effective for both male and female breast cancer.
For Tamoxifen to treat breast cancer, doctors generally recommend a treatment cycle of five to 10 years, depending on the diagnostic characteristics of the cancer. This also indicates that Tamoxifen is a relatively mild drug with no major side effects on human body.
Tamoxifen to treat gynecomastia(gyno)
Men can also develop female-like breasts due to hormone levels, especially during puberty, where androgen levels spike and as many as 70 percent of male teenagers have female-type breasts. Although more than 90% of cases resolve spontaneously within three years, teenagers are at a sensitive time and may have psychologically trouble in female-type breast problems.
Tamoxifen is a safe, well-tolerated and effective treatment for female-type breast problems cause by one’s own hormone levels, such as puberty, avoiding the psychological complications of waiting for them to resolve naturally and the physical hazards of cosmetic surgery treatments.
Tamoxifen for PCT
However, as the bodybuilding population grows, Tamoxifen for the treatment of gyno symptoms caused by exogenous testosterone supplementation and testosterone derivatives. This treatment is PCT.
Although it is possible to build a desired physique through bodybuilding, massive muscle mass is not just a matter of consuming calories and spending hours in the gym, it requires AAS and PED action.
However, exogenous testosterone supplementation, or testosterone derivatives, increases not only testosterone levels in the body, but also estradiol levels.
In men, most estradiol comes from the aromatization of circulating testosterone by fat cells throughout the body, so testosterone supplementation is to some extent equivalent to estradiol supplementation.
Appropriate levels of estradiol play an important role in a variety of physiological functions in men, such as bone metabolism, cardiovascular health and testicular function
But too much estradiol can cause symptoms associated with women, most commonly breast development, known as gyno.
So, the vast majority of bodybuilders who use fitness supplements will have problems with gyno.
Tamoxifen is effective in reducing estrogen levels and restoring endogenous testosterone to a stable, healthy level, as well as reducing the side effects of exogenous hormone supplementation. At the same time, timely PCT prevents muscle loss caused by decreased testosterone levels, which is essential for bodybuilder.