Weight Loss peptides:Semaglutide,Tirzepatide and Retatrutide

The three most widely talked about peptides are Semaglutide, Tirzepatide and Retatrutide. Of the three peptides, Semalutide is the most widely used weight loss peptide, while Retatrutide is the latest. Today, let’s compare these three peptides.

Semaglutide Tirzepatide Retatrutide Working mechanism

• Semaglutide is a GLP-1 receptor agonist;The GLP-1 in Semaglutide shares 94% similarity with the human body and has a longer form of action, making it an optimized version of the human GLP-1.
• Tirzepatide is a double receptor agonist of GIP and GLP-1.Among them, GIP is the same as in the human body, while GLP is 5 times weaker than in the human body.
• Retatrutide is a triple receptor agonist for GIP, GLP-1 and GCGR.GIP-R is 8.9 times stronger than in the human body and can enhance GLR-1R GLR-1R and GCGR are both 2.5 and 2.9 times weaker than the human body.

So what is GLP-1,GIP and GCGR?

GLP-1, also known as glucose like peptide-1, is a hormone produced by intestinal cells.

GLP-1 stimulates and enhances insulin secretion, inhibits glucagon secretion (which increases blood sugar levels), and also slows down gastric emptying, preventing hunger and resulting in decreased appetite.No hunger sensation, reducing calorie intake will result in a calorie difference, thus achieving weight loss effect.

GIP is a single chain peptide hormone composed of 42 amino acid residues.It is secreted by K cells in the duodenum and jejunum of the small intestine. The main regulatory mechanism is that after feeding, nutrients stimulate the small intestine. Endocrine cells (K cells) in the small intestine secrete GIP. After GIP secretion is released into the bloodstream, GIP rapidly increases and reaches its peak within a few minutes. However, its degradation rate is also fast, and most importantly, it is degraded by the ubiquitous degradation enzyme DPP-4 in our body. In the normal human body, insulin secretion stimulated by the pancreatic stimulating effect (after meals) accounts for about 70% of the total insulin secretion, while GIP accounts for two-thirds of the total pancreatic stimulating effect, much higher than GLP-1. GIP has functions such as promoting insulin secretion and improving its sensitivity, increasing GLP-1 secretion, upregulating the expression of p-cell related genes, promoting pancreatic islet cell proliferation, delaying insulin clearance, and promoting neural repair Simply put, GIPR increases insulin secretion during hyperglycemia and stimulates the release of glucagon during hypoglycemia.

Gprotein coupled receptors (GCGR) belong to the B-class G protein coupled receptor family (GPCRs) and play a crucial role in maintaining blood glucose homeostasis in the human body. Other related G-protein coupled receptors include glucagon like peptide-1 receptor (GLP-I), glucagon like peptide-2 receptor (GLP-2), and gastric inhibitory peptide receptor

GCGR is mainly expressed in the liver, followed by the kidneys, heart, adipose tissue, pancreatic islets, and central nervous system. Glucagon not only promotes liver glycogen breakdown, gluconeogenesis, and lipid metabolism, but also has a certain regulatory effect on insulin secretion, appetite, and amino acid metabolism.

Semaglutide,Tirzepatide,Retatrutide ,these three products have their own consumer groups.Even though the new generation Retatrutide works very well as a triple stimulant, there are still people who give feedback that they prefer Semaglutide and Tirzepatide.

Semaglutide Tirzepatide Retatrutide,which is best on Weight Loss?

So let’s take a look at the experimental data and see which one performs best.

Semaglutide Tirzepatide Retatrutide weight loss data

• The average weight loss after 68 weeks of Semaglutide was about 15 percent (34 pounds);
• The average weight loss after 72 weeks of Tirzepatide was about 22.5% (52 pounds).
• The average weight loss of Retatrutide after 48 weeks of use was about 24.2 percent (57.8 pounds).

Only from the experimental data, Retatrutide has a better weight loss effect. Among which, the weight loss data of Tirzepatide is close to Retatrutide , but it is important to note that Tirzepatide is for 72 weeks, while Retatrutide is for 48 weeks. So, obviously, Retatrutide loses more weight and loses weight faster.

So, when compare with Semaglutide Tirzepatide Retatrutide together, is Retaturtide the first choice ?

I can only say that what suits oneself is the best. Retatrutide is more suitable for overweight individuals.

FDA Approval

In fact, more people lose weight using Semaglutide than Retatrutide . It has to do with whether it gets FDA approval or not.

• Semaglutide was first approved by the FDA for the treatment of type 2 diabetes in 2017, and then officially approved by the FDA for weight loss in 2021.
• Tirzepatide received FDA approval for the treatment of type 2 diabetes in 2022, followed by clinical trials for weight loss, still awaiting FDA Approval for weight loss.
• Retatrutide , which is directly focused on weight loss, is not being developed to treat type 2 diabetes as a priority, but rather to treat type 2 diabetes and lose weight in several trials simultaneously. The developers’ confidence in Retaturtide can also be seen here.

Semaglutide Tirzepatide Retatrutide review

By comparing the three peptides Semaglutide,Tirzepatide,Retatrutide, we can see that Retaturtide is one of the peptides that loses weight faster and more weight, but it is still waiting for FDA approval. Semaglutide and Tirzepatide are currently used by more people, and if these two peptides can help you lose weight effectively and sustainably, congratulations.

Depending on your physique and tolerance, if you use these two weight loss peptides and find that the effect is not ideal, then Retaturtide is your hope. Experimental data of Retatrutide have demonstrated that it is an excellent weight loss peptide.