Semaglutide maximum dosage 2.4mg doesn’t lose weight causes and solutions

When Semaglutide is used for weight loss, the maximum dose is 2.4mg per week. When you start titration at a low dose, some people don’t lose weight, and some people lose weight at a low dose. If you do not lose weight by titrating at low doses up to the maximum weight loss dose of 2.4mg, then continuing Semaglutide may and will not lose weight. If weight is lost during titration from a low dose to a high dose, and then after a period of time at the highest dose of 2.4mg, what is the reason for Semaglutide no longer lose weight? Is there a solution?

Semaglutide plateau

A plateau is common in the use of weight-loss drugs. Semaglutide will also plateau. There are many reasons for this. It may be that over time, the body develops a tolerance to Semaglutide, which reduces its effectiveness and slows or stops weight loss. Or after a certain amount of weight loss, genes begin to resist further weight loss, by slowing down the metabolism and other ways to avoid weight loss. It is also possible that some other drugs affect the effectiveness of Semaglutide.

If it is due to the body’s own reasons, the Semaglutide appears a plateau and cannot lose weight intermittently, do we have a solution?

Solution for failure of maximum dose of Semaglutide 2.4mg

Restart

First, 2.4mg per week is already the maximum dose, and we can’t break the plateau by increasing the dose. Restarting dose-titration after stopping Semaglutide may solve the problem of Semaglutide failure in some people. Semaglutide has a half-life of about 7 days, and body takes about 5 weeks to  metabolize after withdrawal. After the body metabolize Semaglutide, titrations from the initial dose to the higher dose can restore the body’s sensitivity to the drug and continue to lose weight.

Change medication

If Semaglutide does not lose weight after re-titrating the dose, you may consider replacing it with another drug to help with weight loss. In recent years, there are many new weight loss drugs, we began to have a lot of choices, Tirzepatide and Retatrutide are new weight loss drugs.

Combined use

Sometimes, when one drug is no longer working, adding another can improve the overall effect. Semaglutide is a GLP-1 receptor agonist, Cagrilintide is an Amylin receptor agonist, studies have shown, The combination of Sema and Cagri resulted in greater weight loss than the combination of Semaglutide alone or Cagri alone.

Of course, you should seek the advice and help of your doctor before making any decision. In summary, there are several possible reasons for Semaglutide failure, including drug tolerance, lifestyle changes, health conditions and drug interactions. Some solutions to the failure of Semaglutide include retitrating the dose, finding new alternatives, or combining them with other drugs.