Peptides Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary
Product Name:Gonadorelin
CAS:33515-09-2
Sequence:P-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
MF:C55-H75-N17-O13
MW:1182
Purity:above 98%
Specification:2mg/vial, 10mg/vial
Appearance:White Lyophilized Powder
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.
Gonadorelin Benefits
Beofore we know the gonadorelin benefit,we need to know how gonadorelin work first.
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Gonadorelin benefits:In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that control by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Gonadorelin benefits:Systemic – Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Gonadrorelin also increase Follicle-stimulating hormone (FSH) production and release by gonadorelin, but to a lesser degree.
Gonadorelin benefits:In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin use to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
Gonadorelin clinical benefits
Gonadorelin benefits mainly in the clinical differential diagnosis of male or female reproductive disorders caused by hypothalamus or hypophysis, atrophic gonadal insufficiency, galactorrhea amenorrhea, primary and secondary amenorrhea, menopause and precocious menopause, pituitary tumor, pituitary organ damage and de facto hypothalamic dysfunction.
It is a synthetic gonadotropin releasing hormone, which belongs to peptide compound and is decapeptide.
The indications Gonadorelin benefit are as follows:
1. For the diagnosis of hypothalamus pituitary gonadal dysfunction.
2. To treat the infertility caused by amenorrhea, gonadotropin insufficiency and polycystic ovary.
3. Gonarelin or its analogues buserelin, goserelin, leuprorelin, nafarelin and triptorelin can also use for contraception, cryptorchidism, malignant tumors (especially prostate cancer), delayed and early puberty.
4. It can also use for endometriosis.
5. It is for ovulation induction to treat infertility and primary ovarian insufficiency caused by hypothalamic amenorrhea, especially for patients with clomiphene ineffectiveness.
6. It is also used for cryptorchidism, androgen excess and pituitary tumor in children. The drug should be used under the guidance of a doctor.
Gonadorelin bodybuilding Benefits
As the Systemic – Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland,this Gonadorelin benefit also used by many bodybuilders to grow muscles.
Gonadorelin peptides Dosage for bodybuilding benefits
Usually,If you are using it for the first time, the best initial Gonadorelin dosage is 2mg. As the body gradually adapts, increase the dose appropriately.