Retatrutide dosage calculator: to know the right dosage of LY-3437943

As a newest weight loss peptide Retatrutide, also call LY-3437943, the use and the right dosage may be unfamiliar for us, today, we will talk about Retatrutide dosage calculator.

What is Retatrutide LY-3437943?

Retalutide, a new drug in development for the treatment of obesity, overweight, is a triple receptor agonist that activates the GLP-1 (glucagon-like peptide-1) receptor, the GIP (Glucose-dependent insulin stimulation) receptor, and the GCG (glucagon) receptor. Through these three receptors, Retatrutide acts to suppress appetite, delay food digestion, increase satiety, and reduce hunger, in addition to inhibiting fat production and increasing lipolysis by acting on GCG receptors, while preserving lean muscle mass. In the process, it generates energy for areas such as skeletal muscle, improving the user’s exercise level.

How to use Retatrutide with the right dosage

There is no official Retatrutide dosage calculator information on the market, and we have to seek for its right dosage from clinical trials.

In trial, Retatrutide was administered at doses of 1mg, 4mg, 8mg and 12mg per week in obese and overweight people. After 4 weeks of use, the average body weight of the subjects decreased by 7.2%, 12.9%, 17.3% and 17.5%, respectively. In the placebo group, the decline was 1.6%. After 48 weeks of treatment, the mean weight loss was 8.7%, 17.1%, 22.8% and 24.2%, respectively, compared with 2.1% in the placebo group.

In trials, it is generally considered that if the weight loss is greater than 5%, the drug is considered to have a weight loss effect. We can see that a weekly dose of 1mg of Retatrutide can achieve weight loss of more than 5%. Therefore, we can choose a dose of 4mg per week according to our actual situation and needs, which is a moderate and safe dose. Of course, if you want to reduce your target weight faster, you can also choose a dose of 8mg per week, but the maximum dose per week should not exceed 12mg.

How to manage you initial dosage?

In the Retatrutide type 2 diabetes trial, the doses used were 0.5mg, 4mg, 8mg, and 12mg. The 4mg and 8mg weekly doses involve starting doses of 2mg and 4mg, respectively. So, is the initial dosage of 2mg good for weight loss or the initial dosage of 4mg good for weight loss?

In the trial, when the weekly dose was 4mg, the initial dose was 2mg, and the average weight loss after 36 weeks was 7.92%; When the initial dose was 4mg, the weight loss after 36 weeks was 10.37%. From this data, when the weekly dose is 4mg, choosing the starting dose of 4mg can work faster and achieve more weight loss.

When the weekly dose was 8mg and the initial dose was 2mg, the mean weight loss at 36 weeks was 16.81%; When the starting dose was 4mg, the average weight loss after 36 weeks was 16.34%. From this data, there was little difference in weight loss, but the larger starting dose did not show an advantage.

Retatrutide dosage review

According to the above analysis, if the weekly dose of Retatrutide is 4mg, it is not necessary to start with a low dose, but directly start with a dose of 4mg. If you choose the dose of 8mg per week, you can start with the lowest dose of 2mg per week and slowly increase to 8mg. If there is a dose of 12mg per week , we should use it from the starting dose of 2mg.

And so on, if your weekly dose is 5mg, the starting dose can be either 5mg directly or 2.5mg. If your weekly dose is 10mg, the starting dose should be 2.5mg.