Reta stack: Which peptide does Retatrutide stack better with?

On Semaglutide and Tirzepatide, most people use it alone, however, when it comes to Retatrutide, Reta stack is a very much discussed topic. Is Retatrutide suitable for stack, and which peptide does it stack better with?

About Retatrutide Stack, have discussed in the previous article . In summary, Reta is a very effective weight loss peptide, which can achieve good weight loss results without stacking with other peptides. However, since the best weight loss results from Reta appear after 4 months, people can’t wait to stack up after 3 months of using Reta and still not seeing significant results. Because during these months, you may eat more than you do on Sema and Tirz, and worry that excessive calorie intake will lead to weight gain, and stack Sema or Tirz can solve this problem. Therefore, make many people will stack.

People will stack Reta with Sema or Tirz, etc., also because many people get ideal results in such stacks. At the beginning of using Reta, stacking Reta with Tirz or Sema can effectively eliminate food noise and avoid weight loss stagnation or weight gain due to excessive intake of calories when Reta has not yet played an appetite suppressing role.

Reta stack with Sema or Tirz

The effect of using Reta is similar to that of using Sema or Tirz stacks, because adding Sema or Tirz to Reta is mostly to suppress appetite, while adding Reta to Sema or Tirz is mostly to increase energy levels. At low doses of Reta, this is a strategy worth considering. But when the dose of Reta is titrated to a high enough level, such as 8mg per week, it is a good appetite suppressant.

Another concern about using GLP-1s stacked with Reta is that Reta itself is a triple receptor agonist. Compared with Sema, Reta also acts on the GLP-1 receptor and has more effects on the GIP and GCG receptors than Sema. Compared with Tirz, Reta also acts on GLP-1 and GIP receptors, and has more effects on GCGR. Most importantly, Reta is a designed unbalanced receptor agonist, and the use of GLP-1+GIP+GCG receptor agonists alone will not achieve the effect of Reta. This is also one of the main reasons why Reta has received great attention since its development. Because Reta is a designed unbalanced receptor agonist, it itself acts on GLP-1 and GIP receptors, if the addition of Sema or Tirz, it may disrupt the balance of Reta and affect the function of Reta.

However, people still stack Reta with GLP-1s, and they do make good gains. However, in addition to GLP-1s, we can also consider other peptides, such as Cagri

Reta stack with Cagri

Cagrilintide is a long-acting analogue of amylin.

Cagrilintide is an analog of amylin, a peptide hormone that plays a role in glucose regulation and satiety. It is designe to mimic the effects of the natural hormone amylin. Amylin helps with weight loss by suppressing appetite and slowing stomach emptying, and on top of that, amylin also regulates blood sugar levels to avoid hunger and overeating that can trigger by rapid drops in blood sugar. Amylin also helps the body use glucose more efficiently by improving insulin sensitivity, which reduces fat storage to support weight loss.

Cagrilintide works through these mechanisms to help reduce calorie intake and promote weight loss. In contrast to Retatrutide, they both help with weight loss, but they work on completely different receptors. Combining Retatrutide with Cagrilintide stack does not affect the sensitivity of the receptor and is more friendly to long-term medication. We can easily see on the web that people have used Retatrutide and Cagrilintide stack and break the plateau for better weight loss results. Cagrilintide is also suitable for stacking with Semaglutide and Tirzpetide.