Tesamorelin is derived from GHRH and promotes the release of GH and IGF-1

Tesamorelin, a synthetic form of growth hormone-releasing hormone (GHRH), FDA approve it in 2010 for the treatment of HIV-related disorders of fat metabolism. Because FDA approve it to reduce belly fat in HIV patients, would we think it useful for fat loss? And because it has the effect of GHRH, would we assume that it helps to raise GH and IGF-1 levels? So what are the facts, and why do Bodybuilders use Tesamorelin?

Tesamorelin and GHRH

Tesamorelin derive from GHRH and base on all 44 aminozuursequenties van GHRH, with modifications added at the n-terminal. It is a modified GHRH. This modification increases its plasma stability and reduces renal clearance, making it more stable. It also increases its membrane permeability, making its effect more effective; It also lengthens its cycle half-life.

GHRH is a growth hormone-releasing hormone naturally produced by the human body that stimulates GH secretion by acting on GHRH receptors. GHRH is released as a pulse and stimulates GH pulse release. GH promotes liver secretion of IGF-1 and stimulates gluconeogenesis. GH is essential for maintaining muscle and bone mass and affects fat distribution in the body. Daarom, the effect of Tesamorelin on the human body is similar to that of GHRH, mainly through the action of GH and IGF-1.

Tesamorelin and fat loss

HIV patients after antiretroviral treatment, will affect the distribution of fat in the body, a large amount of fat deposite in the abdomen, forming typical post-treatment symptoms.

Clinical trials have shown a 10-20% reduction in abdominal fat in patients after 3-12 months of treatment, and it is well tolerated with no side effects associated with GH excess.

Belly fat is often more difficult to get rid of than fat in other areas, and Tesamorelin helps to reduce belly fat in a targeted way.

Why do Bodybuilders use Tesamorelin?

Compared with the direct use of GH or IGF-1, the use of Tesamorelin acts on the front end of GH to stimulate the pulse release of GH, and does not produce the side effect of excess GH, which is relatively safer.

The use of Tesamorelin plays a similar role to GH, in addition to reducing fat, increasing lean muscle mass, maintaining bone health, improving overall metabolic levels, and speeding up post-workout recovery. Dus, bodybuilders use it as one of the supplements.