Is it necessary to stack Semaglutide or Tirzpatide if you are already using Retatrutide?

Semaglutide is a GLP-1 single receptor agonist, Tirzpatide is a GLP-1 and GIP double receptor agonist, and Retatrutide is a GLP-1, GIP and GCG triple receptor agonist. From their mode of action, we would think that there is a progressive relationship between them. If there is a progressive relationship between modes of action, does that mean there is also a progressive relationship between their effectiveness? So, if we are using the triple receptor agonist Retatrutide, is it necessary to stack Semaglutide or Tirzpatide?

In the use of weight loss peptides, many people are stacking these three peptides, and it has been shown that the effect is better after stacking. If Retatrutide is already the best of the three of them, is it necessary to stack it with weight loss peptides that are not as good as it?

Recently, the idea that Retatrutide doesn’t need stacking has gained a lot of support, and the reasons are summarized below.

Do not understand the mode of action of Retatrutide

Retatrutide not simply synthesize to stimulate GLP-1, GIP and GCG receptors, respectively. Reta design to lose weight in a way that is exactly eight times as effective as naturally occurring GIP (Tirzpatide is twice as effective as naturally occurring GIP), while having less effect on GLP-1 receptors than Tirzpatide. Both Semaglutide and Tirzpatide work by getting you to eat less and weigh less. It’s different with Reta, where you can eat normally and then lose weight normally and get better results than with Sema and Tirz. Retatrutide is a non-equilibrium triple receptor agonist by design. Other companies designed balanced triple receptor agonists to lose weight, but eventually stopped the trials. The action of balanced triple receptor agonists is similar to the pattern of stack, so the failure of these drugs illustrates that the effect of simple stack is not obvious.

The idea of controlling calorie intake

People experienced significant appetite suppression when using Semaglutide and Tirzpatide. Controlling calorie intake is the basic operation of weight loss. When you use Retatrutide and you can eat again, you worry about eating too much to lose weight, and you want to control your appetite with Sema or Tirz. Reta actually loses weight by converting fat into glucose, the part of fat that provides the body with energy and can fight hunger, but only if you reach the optimal dose of Reta. The optimal dose of Reta is 9mg, which needs to titrat gradually from 2mg to 9mg over a period of 4 months. Some people expect to see the weight loss effects of Reta soon and therefore do not give Retatrutide enough time to reach the optimal dose.

In pursuit of rapid weight loss

For the above reasons, the best weight loss from Retatrutide comes after 4 months, and people want to stack up when they haven’t seen significant results after 3 months of using Reta. During these months, you may eat more than you do on Sema and Tirz and worry that excessive calorie intake will lead to weight gain, and stack Sema or Tirz can solve this problem. Therefore, make many people will stack.

This part of the theory supports the idea that Retatrutide doesn’t need a stack. What do you think? Do you stack Retatrutide with Semaglutide or Tirzpetide?