How to solve the problem that semaglutide weight loss does not work after the plateau?

Weight-loss drugs have a plateau, after which further weight loss is slowed or stopped. What should I do when semaglutide weight loss plateau appears ?

Semaglutide plateau

Semaglutide weight loss As with other weight loss methods, the body will eventually stabilize at an appropriate weight, which may or may not be the user’s goal weight. If you want to continue to lose weight after reaching the weight loss plateau of the drug, or to avoid weight regain, you need to take the drug for life.

Semaglutide is an FDA-approved weight loss drug. It mimics a naturally occurring hormone that provides the brain with a sense of fullness, slows digestion, and allows food already consumed to leave the body more slowly, successfully helping many obese people lose significant amounts of weight. However, after the weight reaches a certain point, the rate of weight loss slows down until it stops.

Semaglutide plateaus after about 60 weeks of continuous use. At this point, the user has usually lost a significant amount of weight and is gradually approaching a healthy weight, and the body is more inclined to retain calories to protect itself.

At the beginning of weight loss, when you reduce your energy intake, your body will meet its energy needs from other sources such as glycogen (including breaking down fat), which will lead to weight loss. Over time, as the weight lost gradually increases, the body compensates by slowing down the metabolism. When your metabolism is equal to the amount of energy you take in from food, you’ve hit a plateau. This is the genetic protection of the body, which also leads to the cessation of weight loss.

How to solve the semaglutide plateau

If you need to cross the plateau and start losing weight again, you need to change the body’s energy balance again. This can be done by changing your diet or increasing physical activity.

Another way to change the plateau is to increase the dose of the drug. The dose of Semaglutide is 1mg to 2.4mg per week, with gradual increases from the lowest dose to the highest dose. However, after reach the maximum dose, we can’t increase the dose, otherwise it will bring more side effects. So increasing the dose of the drug is limite.

The slimming peptide Tirzpatide and Retatrutide developed successively also indirectly solved the problem of plateau of Semaglutide. Semaglutide is a single receptor agonist of GLP-1, Tirzepatide is a double receptor agonist of GIP and GLP-1. Retatrutide is a triple receptor agonist for GIP, GLP-1 and GCG. Thus, there is equivalent to a progressive relationship between the three drugs, and after reaching a plateau with single-receptor agonists, dual-receptor agonists would work.

However, in the actual process of weight loss, if not only rely on weight loss drugs, but can cooperate with physical activities, it will be more healthy weight loss. After reaching the plateau, actively participate in physical activities, even if the weight is no longer loss, but the body composition is changing. Your body will be more symmetrical, your posture will become better, and your health will be greatly improve.