How to solve Enclomiphene low libido side effects

Rather than directly using exogenous testosterone replacement therapy (TRT), some men diagnosed with low testosterone levels prefer to try Enclomiphene to help promote the production of endogenous testosterone, thereby increasing their testosterone levels. Compared to TRT, enclomiphene brings low libido side effects, so some men have to give up using it.

How does Enclomiphene increase endogenous testosterone levels

Enclomiphene is a selective estrogen receptor modulator, acting in the same way as Clomiphene. By antagonizing the effect of estrogen in the pituitary gland, Enclomiphene makes HPTA (hypothalamic-pituitary-testicular axis) continue to act positively and stimulate the production of testosterone by testis, thereby increasing the level of autocrine testosterone.

Enclomiphene cause low libido

A 40-year-old man who normally felt fine had no obvious symptoms of low testosterone. Influenced by his friend, he also went to test his own testosterone levels, which showed that his Total T was 380 ng/dl and his Free T is 7.3 ng/dl. Tests showed he had low testosterone and he was given 12.5mg of Enclomiphene a day. A month later, his total T had risen to 798ng/dl and his Free T had also increased to 16.4 ng/dl.

Enclomiphene doubled his testosterone levels, however, in addition to the benefits of high testosterone levels, his libido was greatly suppressed.

Another 50-year-old male user takes Enclo at a dose of 25mg three times a week to treat low testosterone levels. Enclo does help raise testosterone levels, but sex drive is rarely experienced while Enclo is being used, and can return when the drug is discontinued.

Another man who used 9.37mg of Enclo a day to treat low testosterone levels also experienced low libido (but still can get hard).

Why does Enclomiphene inhibit libido compared to Clomid?

Clomid is equivalent to 38% Zuclomifene (estrogen receptor agonist) and 62% enclomifene (estrogen receptor antagonist). Therefore, Enclomiphene is used to reduce the side effects of estrogen. There are many factors that affect libido, and estrogen levels happen to be one of them.

Enclomiphene dosage

The usual Enclomiphene dose is 12.5mg or 25mg per day. However, the recommended dose for most people who have used Enclo is 6.25mg ED. enclomiphene, at a low dose, maintains the function of estrogen without affecting libido. If the libido problem does not improve, the dose may be changed to EOD, or E3D.