What is PT-141?
PT-141 peptide (Bremelanotide) is a highly potent synthetic peptide analogue of α-MSH that may elicit aphrodisiac effects through stimulation of melanocortin receptors. PT-141 (Bremelanotide) consists of seven amino acids and is a cyclic, shortened lactam variant of alpha-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of physiological functions. In studies, bremelanotide induce lordosis in an animal model and was also effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).
PT-141 peptide or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 peptide is from the tanning peptide Melanotan 2, which is a peptide hormone naturally produce in the body that stimulates melanogenesis that know as alpha-Melanocyte stimulating hormone. MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 peptide has show in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 research for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
PT-141 chemical info
Product Name: PT-141
Synonyms: Bremelanotide, PT-141 Acetate
CAS: 189691-06-3
MF: C50H68N14O10
MW: 1025.2
Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Appearance:Sterile Filtered White Lyophilized (Freeze-Dried)
Purity:Above 98%
Packing:2mg/vial;10vials/box
Storage :Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should store at 4° C between 2-21 days and for future use below -18° C.
PT-141 and Melanotan II
When we talk about PT141, there comes out Melanotan I and Melanotan II .
Melanotan I is Afamelanotide, first discovered in 1980. it is not so much discovered as direct developed.
Melanotan I develope from α-MSH, an important melanocyte-stimulating hormone that stimulates melanocytes. It originally develope to prevent blisters or itching cause by direct sunlight from EPP.
However, during the study, Melanotan I develop Melanotan II with minimal sun exposure. Melanotan II was first developed as a tanning agent.
Then an even luckier thing happened when Mac Hadley, a scientist, injected himself with a double dose of Melanotan II, resulting in eight hours of erections. The researchers then began targeted development of the part of the sexual aroused of Melanotan II, resulting in PT141, also known as Bremelanotide.
In the United States alone, about 20 million men have ED and about 15 million women have HSDD.
PT-141 for men and women
Unlike some drugs that only affect men, PT141 works in both men and women.
PT141 is the only FDA-approved drug (approved in 2019) for sexual arousal in women, though there are plenty of drugs that work for male arousal, including Viagra, Cialis or Levitra. It is important to note that PT141 is only effective in pre-menopausal men and women, regardless of whether use in men or women.
PT141 works through the nervous system, not the cardiovascular system. It does not just cause an erection, but provides the motivation for sexual desire and erection by acting on the nervous system.
Unlike Viagra, Cialis or Levitra, which are known to work through the cardiovascular system and may contribute to erections (prolonged and often uncomfortable erections), headaches and congestion, PT141 works through the brain and nervous system and stimulates dopamine release, More is a psychological to physiological impact, so that people are more inclined to produce sexual motivation or sexual desire from the psychological.
For those who still can’t achieve an erection with Viagra, Cialis and other drugs that act through the cardiovascular system, a normal erection can be achieved with PT141. This shows that PT141 has a better mode of action.
PT141 is a peptide that works by mimicking hormones present in the body and is safer and more effective than other drugs.
As peptides, the only concern is probably storage, since they tend to be stored in cold storage. Need to store PT141 in a refrigerated environment, but PT141 is stable at room temperature for a week, so we can carry PT141 on travel.