Hexarelin Acetate difference from Tesamorelin and Sermorelin acetate in stimulating HGH release

Compared with directly supplementing HGH to increase HGH levels in the body, people are more inclined to use some compounds to stimulate the natural release of GH, thereby increasing HGH levels. Hexarelin Acetate, Tesamorelin, and Sermorelin acetate are three peptides that are often discussed in the context of HGH stimulation. While they share the common goal of promoting HGH release, they differ markedly in their mechanisms of action, clinical applications, and effectiveness.

Hexarelin Acetate: HGH releasing peptide

Hexarelin Acetate, a member of the growth hormone-releasing peptide (GHRP) family, is a synthetic peptide used to stimulate HGH secretion. It does this by binding to the growth hormone secretagotor receptor (GHS-R1a), which is located on the surface of pituitary cells. Activation of this receptor leads to increased release of growth hormone. Hexarelin is popular for its potential to promote muscle growth, reduce body fat, and improve endurance, making it a top choice for athletes and bodybuilders.

Tesamorelin: Targets abdominal fat

Tesamorelin, unlike Hexarelin, primarily use for different purposes. It belongs to the GH-releasing hormone (GHRH) category. Hexarelin activates the GHS-R1a receptor and Tesamorelin acts on the GHRH receptor. Tesamorelin is an FDA-approved drug for reducing excess abdominal fat in HIV-infected patients with lipodystrophy. It does not directly stimulate the release of growth hormone, but rather stimulates the body to produce more of its own growth hormone, specifically targeting abdominal fat, which is a common problem in these patients.

Sermorelin acetate: a precursor for the production of growth hormone

Like Tesamorelin, Sermorelin acetate belongs to the GHRH group of peptides. Unlike Hexarelin, which binds directly to the GHS-R1a receptor, Sermorelin acts as a growth hormone secretor, essentially signaling the pituitary gland to produce and release more growth hormone. Sermorelin acetate commonly use in anti-aging and health clinics to combat the effects of age-related declines in HGH. It can help improve muscle mass, reduce body fat, and enhance overall vitality by supporting the body’s natural growth hormone production.

Key difference in clinical application

While these peptides all have the overall goal of stimulating HGH, their clinical applications are very different. Hesarellin is favore for its muscle-strengthening properties and performance benefits for athletes. Tesamorelin is for the specific purpose of reducing abdominal fat in patients with HIV-associated lipodystrophy. Sermorelin, on the other hand, more commonly use for anti-aging and health purposes, focusing on general GH enhancement for a more youthful and energetic feeling.