GLP-1RA Semaglutide(Tirz, Reta) reduces depression and anxiety in users

Since FDA approved Semaglutide for the treatment of obesity, GLP-1RA has occupied the majority of the market for the treatment of obesity. As more and more people use GLP-1RA, including Semaglutide, they found it in addition to helping with weight loss and adjusting the body’s metabolic level, GLP-1RA also affects the user’s mental health, including reducing anxiety and controlling a range of addictive behaviors.

After collecting users’ discussions on Semaglutide, Ozempic, Tirzepatide,Mounjaro, Wegovy and Rybelsus, they found that people have a lot of discussions on depression, mood, mental health, anxiety, obsessive-compulsive disorder, panic, sleep and insomnia.

Potential side effects of Semaglutide include insomnia and its effects on mental health, including depression and anxiety, among others. However, in the course of actual use, many users mentioned the positive effects of weight loss on mental health, especially improving anxiety and depression. These are two contradictory ideas, but they actually happen. Therefore, rather than thinking that GLP-1RA like Semaglutide causes side effects such as anxiety and depression, they think that using them exposes some potential problems that users have.

Study of Semaglutide GLP-1RA against depression and anxiety

In a 2022 study, researchers compared GLP-1RA population data such as Semaglutide (10,690) with those who did not use GLP-1RA (42,776) and found that GLP-1RA users had a lower overall combined incidence of anxiety and/or depression than non-users. The incidence was 9.36 per 1,000 people per year for non-users and 6.80 per 1,000 people per year for GLP-1RA users.

The effect was even more pronounced for women. In the study, women who used GLP-1RA for more than 180 days reduced the rate of anxiety to 2.93 per 1,000 people per year compared to those who did not use GLP-1RA.

This study suggests that GLP-1RA use may have antidepressant and anti-anxiety effects. 

Although the final results indicate that GLP-1RA, such as Semaglutide, has antidepressant and anti-anxiety effects, it is unclear whether GLP-1RA has such effects or whether these benefits are due to the health effects of weight loss.

Because obesity isn’t simply the bloated appearance that comes with being overweight, it’s also linked to infections, joint pain, asthma, depression, and a host of other complications that sometimes make it impossible to lead a more active lifestyle. GLP-1RA, such as Semagutide, has changed the rules of the game and become a lifesaver for many obese patients.

Some say that medical studies have shown that it has other mechanisms of influence on the brain’s reward system and dopamine receptors. Personally, I have suffered from attention deficit hyperactivity disorder, depression, and anxiety all my life, and I have never felt that medication is fully effective. Both Vyvanse and Adderall came close to being effective, but the situation was still dangerous only when they got into my system. Semaglutide, on the other hand, feels like what people say antidepressants are supposed to feel.