Exemestane for PCT raw powder Wholesale Price

For Exemestane , the bodybuilder use the Exemestane with SERM for PCT, which means that Exemestane is available for PCT.

Exemestane for PCT

SERM is a selective estrogen receptor modulator, and both Tamoxifen and Clomiphene belong to SERM.
For Exemestane , AI is an aromatase inhibitor.
As for PCT, bodybuilder uses exogenous androgen supplements in the process of bodybuilding to obtain better body shape and more textive muscles. A large amount of supplemental androgen will not only disturb the hormone balance of itself, but also produce a large amount of estrogen in the body. This is why you need to join the PCT.

In order to prevent the side effects of aromatization (water retention and fat storage), we usually use selective estrogen receptor modulators (SERMs) or more effective aromatase inhibitors (AIS). SERMs (tamoxifen, clomiphene) occupy the estrogen receptor locally, so that the circulating estrogen cannot adhere to the receptor. AI inhibits the production of estrogen by inhibiting the action of aromatase, which converts androgen into estrogen. Two types of AI include suicide steroid inhibitors such as exemestane and non steroidal inhibitors such as anastrozole and letrozole. Exemestane can prevent the rise of estradiol (E2) for a period of time after use, so as to prevent any rebound effect. The drug can almost inhibit the plasma and tissue estrogen level of total estrogen (estradiol-e2) by 85%. Occasionally, synthetic forms of dihydroxytestosterone / DHT (testosterone and drosterone) also use to enhance the anti estrogen effect.

Estrogen effects

Nevertheless, estrogen does play an important role in muscle development. Estrogen makes androgen receptors more receptive to anabolic molecules. The study showed that scientists castrated male guinea pigs and then gave them the powerful anabolic steroid 17 alkylated drug methyltrienone (M3). With castration, mice significantly increased estrogen levels and eliminated their androgens. It was observed that the connection between m3 and the receptor was 500% stronger than that before castration. This explains how important estrogen is for the attachment of steroid molecules to the receptor surface.

Insulin like growth factor (IGF1) is a peptide responsible for muscle development and cartilage regeneration. It is well known that estradiol (E2) is present in the factors released by GH. With the decrease of estrogen, the concentration of growth regulator decreased. Aromatization is a process that promotes the existence of IGF1 peptide.

Exemestic is a very powerful and effective suicidal steroid aromatase inhibitor. The information contained in the Dutch act package describes the ability of the vagin to reduce estrogen level by 85%.

The bactericidal aromatase inhibitor exemestane can permanently inhibit the aromatase bound to it, which makes the enzyme inactive forever. The body will eventually produce more aromatase, but the currently bound enzymes bind indefinitely, eliminating any risk that estrogen will rebound. This is not related to the other two main aromatase inhibitors (anastrozole and letrozole), which are non suicidal aromatase inhibitors that bind to aromatase only for a limited time before aromatase inhibitor debinding and metabolism. If the non suicidal aromatase inhibitor suddenly stops, the aromatase that has not been metabolized out of cardiopulmonary bypass will be released again and begin to turn androgen into estrogen at an extremely fast rate. This is not the case with yimeitan.

Exemestane increase testosterone level

Studies have shown that exemestane can increase the level of endogenous natural testosterone in men by 60%, which is quite significant, especially after only 10 days. That’s why some people included it during PCT. Like letrozole, exemestane stimulates the pituitary to release more luteinizing hormone (LH) and follicle stimulating hormone (FSH), which are essential for natural testosterone production. And exemestane has been shown to have a slight androgen effect and the ability to increase the production of insulin-like growth factor-1 (IGF-1). This is beyond the reach of other anti female drugs. By using exemestane during PCT, individuals received an increase in the required testosterone for recovery, but also produced a stronger anabolic atmosphere with the increase of IGF-1. This is useful for steroid users because it can better protect their lean tissue during use.

Exemestane is an aromatase inhibitor. Its structure and function are similar to formestane, but the effect is much stronger. Aromatase inhibitors usually isolate aromatase to prevent the production of estrogen. Bodybuilders who use aromatized steroids usually use it to inhibit the side effects of feminization. Such side effects include bitch’s milk, increased fat and water storage reactions. Sometimes aromatase inhibitors can also be used to reduce fat and improve muscle separation. Exemestane is one of the most powerful aromatase inhibitors available. The most recognized clinical trials in women show that exemestane has an anti estrogen efficiency of 85%

Why do androgen supplements produce estrogen?

This is because of the natural presence of aromatase in the body, the presence of aromatase, so that the intake of male hormones in the body aromatize, the production of large amounts of estrogen. When large amounts of estrogen accumulate in the body, it is associated with female characteristics, most commonly breast development and water retention.
For Exemestan we know that Exemestan is FDA approved to treat women with breast cancer because for Exemestan can effectively inhibit aromatase activity in the body, thereby reducing circulating estrogen levels throughout the body. Use of Exemestan in a steroid cycle can prevent estrogen-related side effects.
So, Exemestan is clearly permissible for PCT.

FDA approved AI also has anastrozole and letrozole, which temporarily inactivate aromatase by inhibiting aromatase activity, but for Exemestan is an irreversible steroid aromatase inactivator that can permanently inactivate aromatase.
So, Exemestan for PCT, works better than other AI.

Why use Exemestan mixed with SERM for PCT?

AI Exemestan is inactivate aromatase so that androgens in the body do not convert to estrogen. SERM tricks the brain into lowering estrogen levels in the body and restoring endogenous testosterone to a stable, healthy level while reducing the side effects of exogenous hormone supplementation.
Refer to the working principle above, SERM can be used in a PCT cycle after the completion of a bodybuilding cycle, but AI Exemestan can be used for not only after a PCT cycle but also in a normal bodybuilding cycle.

In bodybuilding cycle,when we intake of exogenous androgens, we have to prevent androgens convert into estrogen in the body. Exemestan blocks the action of aromatic enzyme, so that aromatic enzyme cannot convert androgen to estrogen.When Exemestan reduce estrogen at the same time, also increase the use rate of androgen. It makes Exemestan more conducive to bodybuilding.

Exemestane is a weak androgen, if use Exemestan for PCT alone, it is essentially supply additional androgen in body,so it will interfere endogenous androgen secretion. The essence of PCT is to reduce or stop the supplement of exogenous androgen, so that the androgen level in the body can return to normal as soon as possible.

AI exemestan with SERM

The bodybuilder will use AI Exemestane and SERM in PCT cycles,Exemestan’s weak androgen will have little effect on male hormones, and can effectively increase androgen level for when used with SERM, both can reduce water retention, prevent and treat breast development. So we can use Exemestan with SERM.

As mentioned earlier, we can use it in bodybuilding, so you don’t have to wait for the PCT to use Exemestane . As a weak androgen, bodybuilding supplements usually are also male hormones and the two do not interfere with each other. Exemestane can also block the action of aromatase during bodybuilding to avoid the conversion of added androgen to estrogen and increase the utilization rate of exogenous androgen. At the same time, estrogen – induced male breast development is not a single day, it can accumulate over the course of the exercise cycle, which could avoid gyno by Exemestane during exercise.
So, Exemestane if for PCT, but also for everyday bodybuilding.