Compare with TB500 and Tβ4 to know TB500 benefit for bodybuilding sale with good price

If we want to know about TB500 for bodybuilding, we have to know the relationship between TB500 and Tβ4 at the first.

What is Tβ4?

Tβ4 (Thymosin-beta4) is naturally present in the body, originally isolated from the thymus gland, and gradually found in many other tissues with the development of biotechnology.  It is a major cellular component in many tissues and its intracellular concentration can be as high as 0.5 mM.  

Tβ4 contributes to physiological processes such as angiogenesis, wound healing and inflammatory regulation.  After injury, Tβ4 is release by platelets and many other cell types to protect the most severely damaged cells and tissues and reduce inflammation and microbial growth.  

Thymosin is a peptide hormone secrete by the thymus gland, which is located behind the sternum and between the lungs.  

The thymus gland is active only before puberty, after which it slowly contracts and it eventually replaced by fat.  So after puberty, no thymus gland makes Tβ4, and only smaller amounts are produce in other tissues of the body.  

Corresponding studies have also shown that removing thymus organs from adults has little effect on adults, but when thymus organs are removed from newborns, T cells in the blood and lymphatic tissues are depleted and the immune system’s failure can lead to a wasting disease that is gradually fatal.  

Naughty children often make their body out of a lot of wounds, adults always say that children do not matter, soon grow well.  At the time, we might not understood why wounds heal faster in young children. Now, we surely understand why wounds heal more easily, why children have more energy and are more likely to rejuvenate after lots of activity.  This has a lot to do with Tβ4.  

Now that the benefits of Tβ4 are clear, what is the relationship between TB500 and Tβ4?  

The answer is: TB500 is a synthetic peptide that is essentially a short-chain version of the naturally occurring Tβ4.  

TB500 baisc informtaion:

Product Name:TB500
Other Name:Thymosin β4
Sequence: AC-Ser-Asp-Lys-PRO-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-PRO-Leu-PRO-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
CAS No.: 77591-33-4
MF:C212H350N56O78S
MW:4963.49
Purity:above 98%
Packing:2mg/vial and 5mg/vial;10vials/box
Appearance:White Lyophilized Powder
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. 

The relationship between TB500 and Tβ4

Since the relationship between TB500 and Tβ4 is that TB500 is a synthetic version of Tβ4, why supplement TB500 instead of Tβ4 directly?  

This involves the synthesis of  peptides with equal length to Tβ4.  

Peptide synthesis on an industrial scale is an expensive, time-consuming, and highly polluting process, especially for long peptides such as Tβ4.  Furthermore, complete Tβ4 genetically engineered production has failed in several reports due to the sensitivity of small peptides to proteolytic degradation.  Protein tag fusion strategies and excess amino acids have been used to resist degradation to reduce susceptibility.  However, the multiple purification steps and potential immunogenicity are not cost-effective or satisfactory for therapeutic use.  Then came out a short-chain version of Tβ4, TB500. 

TB500 is a synthetic version of the natural peptide Tβ4, which retains the active site of Tβ4 and has its n-terminus artificially acetylated.  

The synthesized TB500 retains the active site of Tβ4 and has the same effect as Tβ4.  

TB500 has a low molecular weight and does not bind to the extracellular matrix. It can travel long distances through human tissue, so it can easily travel through the body to reach local areas, meaning that TB500 does not have to be injected directly into the site of injury to be effective.  

One of TB500’s key mechanisms of action is its ability to regulate the cell-building protein actin. Actin accounts for about 10 percent of the thousands of proteins present in human cells.  Therefore, actin is an important component of cell structure and movement.  

Now we know the relationship between TB500 and Tβ4. Obviously, we can find the TB500 has a huge impact on the athletic crowd.  TB500 helps improve athletic performance as well as post-workout repair and remodeling.