Adipotide target on Prohibitin to reduce fat cells in weight loss

Adipotide is Prohibitin-targeting peptide 1, also known as FTPP, is a weight-loss peptide whose unique pattern of weight loss provides a new way to solve the problem of weight regain in dieters.

Know Adipotide

We know that conventional weight loss methods are usually achieved by suppressing appetite, inhibiting absorption, or increasing satiety. Using these drugs to lose weight, the end result is a reduction in fat cells, and thus overall weight loss. Adipotide has a completely different mode of action. It directly reduces the blood supply to fat cells, which leads to fat cell apoptosis. Therefore, Adipotide works to lose weight by reducing fat cells.

Adipotide come out

Adipotide, whose sequence is CKGGRAKDC-GG-D (KLAKLAK) 2, is an experimental pro-apoptotic drug originally developed to fight cancer by cutting off the blood supply to tumors.

One protein, Prohibitin, is active in obese people, cancer patients and in some cases, such as diabetes, by causing blood vessels to proliferate to supply more of the nutrients and oxygen that fat and cancer cells need. If you could block Prohibitin’s function on the blood vessel wall of these cells, you could make these tissues disappear due to blood vessel atrophy. Adipotide is called Prohibitin-targeting peptide 1, indicating its origin.

How does Adipotide lose weight?

From the previous introduction, we were able to conclude that Adipotide works by binding to Prohibitin on the surface of blood vessels. Once bound, it triggers the death of these blood vessels, effectively starving fat cells (fat cells) of nutrients and oxygen, causing them to die and reabsorb by the body.

Some weight loss methods reduce fat cells by suppressing appetite or inhibiting the absorption of nutrients, thereby reducing weight. After reaching the target weight, stop taking the drug, and through eating and nutrient intake, the volume of fat cells will increase again, resulting in weight rebound.

Adipotide is different in that it consists of two main elements: a homing sequence that binds to specific receptors on the surface of fat cells and a synthetic peptide sequence that triggers cell death.

Once a lipopeptide enters the body, it binds to receptors on fat cells. After binding, the peptide sequence induced apoptosis or programmed cell death of the target cells. This leads to a reduction in the size and number of fat cells in the body, which leads to weight loss. The reduction in the number of fat cells is to reduce fat at the root and avoid weight regain.

Adipotide weight loss concerns

Adipocyte shedding

Adipotide causes fat cells to die by targeting their blood supply. Does the release of a large number of fat cells into the blood after losing the blood supply lead to higher fat levels in the body? If a large number of fat cells release quickly, it may lead to inflammation of blood vessels, metabolic disorders, and so on. The actual results show that when use Adipotide, fat cell apoptosis did not lead to elevated and dangerous levels of fat in the body; instead, the body use shed fat cells as fuel to provide the energy the body needs, thus further reducing food intake.

Kidney problem

In the Adipotide trial, it caused subjects to become dehydrated and have slightly lower levels of phosphorus and potassium. This can have an effect on the kidneys. But when the drug is stopped, these effects disappear.

Many of the weight loss medications we see require long-term use to sustain weight loss. The mode of action of Adipotide makes it unlikely that it will be a long-term weight loss drug, as it is unlikely that we want to destroy all fat cells. After users lose some of their fat with Adipotide, they can maintain their health gains through diet and exercise.

The dosage of Adipotide

In the Adipotide study, doses ranging from 0.03mg/kg/day to 0.1mg/kg/day. Actual human is not clear. Some people on the Internet try to use doses of 0.5mg-2mg/day to lose weight.

In fact, Adipotide is an experimental peptide, and there is no exact human dose.

Adipotide review

People have been struggling to lose weight, so fat storage is the instinct of the human machine to operate. And fat cells are very “stubborn”, it is not easy to make it thin, it is easy to get fat again. This makes it always difficult to lose weight.

As the number of overweight people increases, more and more new weight loss drugs are being develop and approve, and there are many weight loss drugs in development, which provides more hope.

Adipotide fatty peptides represent a new and promising direction in the fight against obesity. Unlike traditional ways of losing weight, by directly targeting cells that contribute to fat storage, this peptide offers a new way to tackle an old problem.

If Adipotide gets approve, it could maintain the target weight for a long time, solving the problem that many overweight people tend to regain weight after successful weight loss.