Does Retatrutide cause blood pressure to rise or fall?

Retatrutide causes blood pressure to rise? Or does it cause blood pressure to drop? Why do different people have opposite effects?

Retatrutide is a novel multi-agonist that primarily acts on GLP-1, GIP, and GCGR (glucagon receptor) and use in weight loss and metabolic health. Regarding the effect of Reta on blood pressure, studies have shown that it may have different results in different populations, either leading to an increase in blood pressure or a decrease in blood pressure. The reasons involve many mechanisms and individual differences.

Retatrutide may cause a drop in blood pressure

Weight loss: Retatrutide is primarily used for weight loss management, and weight loss generally lowers blood pressure. Being overweight or obese increases the burden on the heart, and weight loss can reduce vascular resistance, which in turn improves blood pressure control. For those who have high blood pressure due to obesity, Reta has the potential to improve their blood pressure by promoting weight loss.

Antihypertensive effect of GLP-1 receptor agonists: Reta has a certain blood pressure lowering effect by activating GLP-1 receptor. GLP-1 receptor agonists have been shown to improve endothelial function, reduce vascular resistance, and help regulate blood pressure. Studies have shown that GLP-1 agonists have a certain antihypertensive effect in patients with obesity or diabetes.

Retatrutide may cause an increase in blood pressure

Activation of the glucagon receptor (GCGR) : Retatrutide also activates the glucagon receptor (GCGR), which may increase the activity of the sympathetic nervous system, leading to an increase in blood pressure. Glucagon receptor activation increases glucose output from the liver and promotes lipolysis, possibly triggering a temporary pressure boosting response.

Individual differences and underlying health status: Metabolic status, cardiovascular health and drug response vary widely among individuals. For example, some people have a higher sensitivity to glucagon receptors and may therefore experience an increase in blood pressure after using Retatrutide, while others may benefit more from the blood pressure lowering effects of GLP-1 agonists. In addition, some people may already have high blood pressure, cardiovascular disease, or other health problems that complicate their response to medications.

Changes in electrolyte and water balance: Some patients may experience mild dehydration or electrolyte imbalances when using similar medications, which can have an impact on blood pressure. Glucagon agonists may increase sodium excretion by the kidneys or affect blood volume, which in some cases triggers fluctuations in blood pressure.

In SUMMARY

Retatrutide may produce opposite blood pressure responses in different individuals, depending on the individual’s metabolic status, the drug’s effect on various receptors, and other health factors. Some people may experience a drop in blood pressure due to weight loss and GLP-1 agonists; Others may experience elevated blood pressure due to activation of glucagon receptors or stimulation of the sympathetic nervous system.

If you have a blood pressure change during the use of Retatrutide, especially a significant increase or decrease, you’d better speak with your doctor to evaluate whether the drug use is appropriate for their health condition.