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Recently, a discussion that MK677 methylation brings some epigenetic effects on genes and pass to future generations has caused panic among many users, and today, we will also discuss it.
First, let’s look at the word methylation. Methylation is -CH3, which normally means replacing hydrogen atoms with methyl groups. Is methylation good or bad?
Methylation is the basis of human metabolism, including cell detoxification, neurotransmitter synthesis, cell growth, tissue repair and gene expression. So, methylation is an essential chemical reaction in the human body. Whether methylation is good or bad depends on whether it is in balance in the body.
Among steroids, methylated compounds are more common, because methylation compounds are generally toxic to the liver, so we can easily list methylation steroids, such as methasteron (superdrol), metandienone (dianabol). MK677 is not actually hepatotoxic.
Epigenetics refers to changes in gene expression or cell phenotype that can be preserved and transmitted to offspring through certain mechanisms or pathways when the DNA sequence is unchanged.
However, epigenetic changes are not permanent; they are reversible.
In the case of cancer, for example, genetic changes in cancer patients are not pass on to future generations, however, descendants of cancer patients often perceive a higher chance of developing cancer. This is thought to be epigenetic , in which a patient’s offspring may not develop cancer, but are more likely to develop cancer if they develop the same triggers as their parents.
Similarly, if the parents love sports and get muscle through bodybuilding, then the offspring are more inclined to build muscle easily. However, when he was born, he was still a normal child, and if he did not exercise, he would not gain muscle. In fact, each person has a different degree of difficulty in acquiring muscle, and in the end, it may be that the person who has a harder time acquiring muscle has more muscle because he has worked harder.
What changes will MK677 methylation ghrelin receptors bring to children? Makes them more prone to hunger? Compared to the muscle mass you gain, this may not be a big impact. In fact, most epigenetic occurs only during an individual’s lifetime and does not affect germ cells and pass to the next generation.
For example, junk food is bad for your health, smoking can cause cancer, but with junk food everywhere, people still don’t give up smoking. The use of supplements to build muscle, whether sarms or steroids, can certainly affect the user, any drug instructions list a long list of side effects, depending on the individual’s choice. If I want to use MK677, I need to evaluate the gains and losses for myself, what will I get? At the cost? Do I accept it?