Does IGF-1 lr3 make you bigger?

IGF-1 lr3 is an anabolic peptide commonly use to increase metabolism, promote protein synthesis, and help bodybuilders gain muscle mass. So, obviously, IGF-1 lr3 makes you bigger. Not only that, IGF-1 stimulate testosterone production in testicular interstitial cells and, together with testosterone, mediate some of the growth-promoting effects of androgens in androgen-reactive tissues. So, in addition to building muscle, IGF-1 lr3 really does make you bigger.

Effects of testosterone and IGF-1 lr3 on anabolic reaction of foreskin fibroblasts

In the experiment, the culture was exposed to increased concentrations of IGF-1, or to increased concentrations of testosterone in the presence and absence of IGF-1, and the protein synthesis response was measured.

Protein synthesis increased dose-dependent as IGF-1 concentrations increased between 25 and 100ng/mL. Compared with the control, the maximum increase was 34+/-3%, P< 0.001.

In contrast, testosterone concentrations increased between 1 and 1000nm, and in the absence of IGF-1, the results did not change.

However, if 50ng/ml of IGF-1 is also present, it’s easily to detecte the response to testosterone , and increase testosterone concentration stimulates protein synthesis, 25-57% higher than the value obtain with testosterone alone.

Results obtained with 10-1000nm testosterone concentration plus IGF-1 were compared with values obtained with 1nm testosterone concentration plus IGF-1, and these concentrations caused more significant increases, P< 0.05.

Experiment explain

The figure on the left above shows the protein synthesis response of the hypertrophic organism to IGF-1+ testosterone. With increasing IGF-1 concentration, protein synthesis increased in a dose-dependent manner. The figure on the right above shows the protein synthesis reaction with increasing testosterone concentration in the presence (•) or absence of (○) IGF-I (50 ng/mL).

This study clearly shows that there is an interaction between testosterone and IGF-1 that stimulates total protein synthesis in fibroblasts. If didn’t add IGF-1, even if increase the testosterone concentration to 1000nm, there is no effect on the protein synthesis response of these cells. If add IGF-1, even if the testosterone concentration is as low as 10nm, it will stimulate protein synthesis.

At the same time, we can also see the synergistic effect of testosterone and IGF-1 by comparing the left and right figures in the accompanying figure: testosterone enhances the maximum effect that IGF-1 can obtain.

Therefore, in addition to increasing muscle, the anabolic effects of IGF-1 lr3 also help to improve the effect of testosterone, especially in androgenic tissues. If you experience a loss of libido while using anabolic steroids, using IGF-1 lr3 can help you deal with the problem.