Type 2 Diabetes Treatment Semaglutide 10mg for Healthy Weight Loss

Peptides Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist.

What is GLP-1?

GLP-1, or glucagon-like peptide-1, is a hormone that naturally producing in the body. It mainly produce in the gut. GLP-1 plays a crucial role in regulating blood sugar levels and appetite.

In consuming food, GLP-1releasing into the blood, and it has several effects on the body.

Stimulates insulin release: GLP-1 enhances insulin release. Insulin lowers blood sugar levels by encouraging glucose to enter cells.

Inhibition of glucagon release: GLP-1 inhibits the release of glucagon, another hormone produced by the pancreas. Glucagon raises blood sugar levels by promoting the release of stored glucose in the liver.

Slow gastric emptying: GLP-1 slows the rate at which the stomach dumps its contents into the intestines. This delay in gastric emptying helps reduce the rapid rise in blood sugar levels after a meal.

Appetite suppression: GLP-1 acts on the brain to suppress appetite and promote satiety.

Given these roles, GLP-1 plays a crucial role in regulating glucose metabolism in the body and promoting glucose control. Development of GLP-1 receptor agonists that can mimic the effects of GLP-1 to improve blood sugar control and weight loss in patients with type 2 diabetes or obesity. That’s what Semaglutide is like.

How Semaglutide works?

Peptides Semaglutide, first use to treat type 2 diabetes and obesity, acts as a GLP-1 receptor agonist by mimicking GLP-1 action.

When inject Semaglutide, it binds to and activates GLP-1 receptors locating on various cells in the body, including pancreatic cells.

By stimulating the release of insulin, glucose in the blood encourage to enter cells, thereby lowering blood sugar levels. Sugars that enter the cell also provide energy to the cell;

By inhibiting glucagon, the liver does not produce excess glucose, thereby reducing blood sugar levels.

By slowing stomach emptying, it reduces the rate at which nutrients, including glucose, are absorbed into the bloodstream, helping to control blood sugar spikes after meals. This effect prevents people from feeling hungry as soon as possible and does not produce the desire to eat, which helps people with type 2 diabetes or obesity control their appetite.

Semaglutide also affects appetite regulation centers by acting on the brain, resulting in reduced hunger and increased feelings of gulping. Helps to control appetite and lose weight.

Overall, Semaglutide helps improve blood sugar control in people with type 2 diabetes by increasing insulin release, inhibiting glucagon secretion, and slowing digestion, while having the effect of reducing weight control.

Semaglutide for Weight Loss

In addition to being used to treat type 2 diabetes, Semaglutide has been approved by the FDA for weight loss in 2021.

For decades, Americans have been waging a losing battle against obesity. According to the Centers for Disease Control and Prevention, from 1960 to 2010, the prevalence of adult obesity in the United States nearly tripled, from 13 percent to 36 percent.

According to data from the 2018 National Health and Nutrition Examination Survey, about half of American adults (49.1 percent) are trying to lose weight. Still, the obesity rate rose to a record 42.4 percent that year, according to the CDC.

Obesity is a chronic, life-limiting condition associated with a variety of cardiometabolic diseases, resulting in significant morbidity and premature death.

Drug treatments for obesity have been a volatile area, with many treatments unable to demonstrate enough safety data to warrant FDA approval.

Semaglutide (Wegovy) is one of six drugs currently approved by the FDA for the long-term treatment of obesity. Therefore, you can use it with confidence.

Semaglutide for Weight Loss Trails

Wegovy’s Phase 3 trial, known as the STEP (Semaglutide Treatment Effect in People with Obesity) trial, showed that patients assigned to the drug group lost an average of 14.9 percent of their body weight after 68 weeks of treatment, The control group experienced only a 2.4% reduction. The average weight loss in the somarlutide group was 15.3 kg, and the weight loss was ≥ 5%

Injected semaglutide eliminates the strict guidelines for fasting intake required for oral semaglutide, while higher doses of Wegovy can better cross the blood-brain barrier, thus increasing its weight loss effects.

The trials included participants who were overweight or obese but did not have diabetes, and the key points of the trials were as follows.

Evaluate the weight loss benefits of Semaglutide

Participants were randomly assigned to receive a weekly subcutaneous injection of Semaglutide or a placebo. The results showed that participants who received Semaglutide achieved more significant weight loss than those who received placebo.

The effect of Semaglutide and liraglutide was compared

Participants were randomly assigned to receive either weekly subcutaneous injection of Semaglutide or daily subcutaneous injection of liraglutide. The results showed that Semaglutide was more effective than liraglutide in weight loss.

Evaluate the long-term sustainability of Semaglutide weight loss

Participants were randomly assigned to receive a weekly subcutaneous injection of Semaglutide or a placebo. Over the 68-week study period, Semaglutide showed sustained weight loss.

To evaluate Semaglutide in patients with obesity-related complications such as hypertension and dyslipidemia

Participants received a weekly subcutaneous injection of Semaglutide or a placebo. During the study period (68 weeks), Semaglutide was found to promote weight loss in people with obesity-related complications and improve obesity-related metabolic status.

Semaglutide for weight loss trails is the basis for its FDA approval for weight loss and has also proven its effectiveness in weight loss.

Peptides Semaglutide for weight loss benefits review

In addition to the low-dose Semaglutide used to treat type 2 diabetes and high-dose Semaglutide used for weight loss, when used for weight loss, it can be effective in preventing and treating cardiovascular disease and related complications, including osteoarthritis and sleep apnea. Therefore, losing weight with Semaglutide not only loses unwanted weight, but also improves the overall health of the user.

When Semaglutide is used for weight loss, because the effect of GLP-1 is glucose-dependent, GLP-1 lowers blood sugar only when the blood sugar concentration is higher than the fasting level. Therefore, treating obesity with the anti-diabetic drug Semaglutide does not increase the risk of hypoglycemia in people who are obese but do not have diabetes.

Semaglutide for weight loss dosage

Peptides Semaglutide is used in two ways, one by injection and one by mouth. When it is used to lose weight, there is only one way to use it. When Semaglutide use for weight loss, its dosage is usually higher than it is used to treat diabetes.

Injectable has better bioavailability and avoids gastrointestinal discomfort associated with oral administration, such as nausea, diarrhea, and vomiting. At the same time, oral Semaglutide needs to controll strictly  for the duration of use, and needs to be completely empty, not only can not eat, but also drink or other drugs. To put it simply, take Semaglutide orally first when you wake up that day, and at least 30 minutes after that. Injection is much more convenient. Also, when use Semaglutide for weight loss, it only needs to inject once a week.

Semaglutide for weight loss is available in three doses, 1mg, 1.7mg, and 2.4mg.

Attention

Whether use Semaglutide to treat diabetes or for weight loss, it start at a low dose and then increase it every four weeks (or one month) . That is, choose to use Semaglutide for weight loss, the initial dose is 1mg once a week, after four injections or one month, we can increase the dose to 1.7mg, and after four weeks of  using,  increase the dose to 2.4mg. The maximum dose should not exceed 2.4mg/week. Because the increase of the drug dose is not always proportional to the weight reduction, continuous use at the most suitable dose can obtain sustained and effective wight loss. Too high a dose may bring more side effects.

Obesity is a chronic disease characterized by changes in weight-regulating hormones that lead to easy regain after weight loss. Therefore, in order to maintain weight loss, weight loss should be sustained at the appropriate dose, while high doses are expected to achieve rapid weight loss results.

Semaglutide side effects

The side effects of Semaglutide for weight loss and diabetes are basically the same.

Gastrointestinal problems

Common side effects of Semaglutide are nausea, diarrhea, vomiting, and constipation. These side effects mainly occur at the beginning of use or when the dose increase, and over time, the symptoms will gradually reduce or resolve. But some may also persist. Slowly increasing the dose can help reduce this side effect.

Low Blood Sugar

Semaglutide use associate with an increasing risk of hypoglycemia, especially when used in combination with other hypoglycemic medications. Need to be monitor Blood sugar levels  regularly to avoid hypoglycemia.

Thyroid tumor

According to animal studies, GLP-1 analogues associate with the risk of thyroid C-cell tumors. It is not know if the same effect would have in humans. When using Semaglutide, focus on the function of the thyroid gland. Therefore, people with a personal or family history of thyroid tumors or genetic disorders related to endocrine tumors should seek a doctor’s advice before using it.

Pancreatitis

There is a risk of pancreatitis with Semaglutide. Patients should monitor for symptoms such as persistent severe abdominal pain.

Allergy

Severe, life-threatening allergic reactions are rare. If you experience symptoms such as swelling of the tongue or throat, dizziness, or fainting, you should seek medical attention immediately.

Other side effects

Other side effects may include fatigue, dizziness, high blood pressure, increased heart rate and vision problems. The risk is often higher in large doses or when used in combination with certain other drugs. Especially when starting or increasing the dose, we should pay attention to possible side effects.

How can I avoid weight gain after I stop using Semaglutide?

After successful weight loss with Semaglutide, it is also very important to avoid weight regain after stopping use.

First of all, after using Semaglutide to lose weight to the target weight, we should reduce  the dose of Semaglutide gradually  to allow the body to slowly adapt, rather than suddenly stop using in the case of high doses. This is conducive to the transition to the state after drug treatment, to maximize the weight does not regain.

Secondly, we should stick to a healthy diet and regular exercise. Controlling calorie intake and expenditure, combined with exercise to maintain a healthy metabolism, can help with long-term weight control. During this process, we should monitor weight maintain. If the weight increases by more than 1-2 kg within a month after stopping Semaglutide, we need to adjust and restart Semaglutide treatment if necessary.

Finally, 6-12 months after reaching the target weight and stopping the use of Semaglutide, regular review should  conducte to assess weight and lifestyle, etc., and regular tracking and monitoring of corresponding adjustments can  carry out to minimize the occurrence of weight rebound.

Obesity is actually a chronic disease, and like the treatment of high blood pressure is not a quick fix. Be patient, maintain a positive attitude, adhere to a healthy lifestyle, and treat weight management as a lifelong career.