Oxymetholone/Anadrol estrogen side effects – Gynecomastia and water retention

Oxymetholone is the only DHT derivative with estrogen side effects.

Oxymetholone is a DHT derivative. To the best of our knowledge, DHT derivatives are not substrates for aromatase and, therefore, do not bind to aromatase to produce estrogen. However, oxymetholone is an exception, and taking oxymetholone may cause estrogenic side effects that are different from all other DHT derivatives. For example, oxymetholone may also cause side effects of gynecomastia, but it is less likely than other AAS and this side effect is very rare.

Estrogen side effects Gynecomastia

The possible estrogen side effects of oxymetholone are not due to its aromatization, but may be due to its direct binding to and activation of estrogen receptors that cause gynecomastia. Gynecomastia is a condition in which extra breast tissue begins to form in a man’s breasts. A mild form of gynecomastia may resemble swollen nipples, while a severe form of gynecomastia can cause a man’s breasts to look like a woman’s. To prevent gynecomasdia from estrogen side effects, bodybuilder can take anti-estrogen medications such as Nolvadex or Clomid during the oxymetholone cycle.

Water retention

Oxymetholone use during the bodybuilding cycle resulted in significant extracellular fluid retention. Proper water retention may be beneficial during the AAS cycle, as the cell fluid can help produce ATP, increasing muscle size and muscle strength. However, the downside of water retention is that the obtained muscle looks smooth and less defined. Water retention can also cause bloating, especially when taken in high doses or with a high-sodium diet.

So oxymetholone is the choice for fast growing muscles, but not cutting.

Oxymetholone does not always produce significant water retention. If the bodybuilder is on a particularly clean diet and is already lean, then oxymetholone will not retain as much fluid when used. So, bodybuilder, who has already gained lean muscle mass, will make their muscles look fuller after using oxymetholone and won’t have water retention traces. During this time, bodybuilder may also need to use SERM to control the body’s estrogen levels and to control sodium intake. This will give you a dry, full, muscular look.