Hepatotoxicity and hypertension side effects of Oxymetholone/Anadrol

Common side effects of oxymetholone include depression, drowsiness, headache, swelling, rapid weight gain, abnormal erections, altered skin color, nausea, loss of appetite, insomnia, and more. However, the main side effects of Oxymetholone are hepatotoxicity and hypertension.

Toxicity to liver

Oxymetholone is a C17-alpha-alkylated compound that protects it from inactivation through the liver. This gives Oxymetholone good oral activity, remaining active in the blood when taken orally.

At the same time, as with all C17-alpha-alkylated AAS, they cause stress to the user’s liver.

Because Oxymetholone has A saturated A ring, this reduces its hepatotoxicity to some extent; However, studies have shown that it can affect liver health if taken in high doses.

In a 2003 study of 89 subjects taking 100-150mg Oxymetholone daily for 16 weeks, ALT/AST liver enzymes increased more than fivefold in 25% of the 100mg group and more than fivefold in 43% of the 150mg group.

As a result, using Oxymetholone increase the risk of liver damage at high doses and or over a long period of time.

As a result, the Oxymetholone dosage at bodybuilder was kept below 100mg per day.

In another study of 31 subjects who took 50-100mg Oxymetholone daily, the 50mg group did not show any liver enzyme increase, but the 100mg group showed moderate ALT/AST increase.

When bodybuilder uses Oxymetholone to assist bodybuilding, precautions should be taken by using low to moderate doses of Oxymetholone over a relatively short period (4-6 weeks) and, if necessary, some liver protective medication.

Hypertension

High blood pressure is another problem. Basically all AAS affect bodybuilder blood pressure because exogenous testosterone causes negative changes in cholesterol levels. This leads to a sharp rise in LDL cholesterol levels and a drop in HDL levels.

Studies of Oxymetholone have shown that it has a negligible effect on LDL levels, but causes a rapid decline in HDL levels.

In an experiment of 31 subjects, taking 50-100mg of Oxymetholone daily reduced their HDL by 19 and 23 points, respectively.

Since Oxymetholone significantly increases red blood cell count, it can also raise blood pressure. Oxymetholone users had five times the number of red blood cells. As a result, it impair the user’s blood becomes more viscous and blood flow to the heart . Water retention further reduces circulation.

Oxymetholone is an AAS that has a negative effect on the heart due to its effect on HDL cholesterol levels, red blood cell count, and water retention. Bodybuilders with high blood pressure or a family history of heart disease should avoid Oxymetholone.

You may experience nosebleeds and headaches when you take Oxymetholone bodybuilder, which may be a sign of elevated blood pressure.