NPP Steroid nandrolone phenylpropionate dosage and half life for bodybuilders

What is the position of NPP steroid in the huge group of AAS? Under what circumstances do you only choose nandrolone phenylpropionate steroid in your cycle? When we compare NPP vs others AAS, we will know that NPP is the AAS with the highest MA index and NPP not reduce to DHT by 5AR.

To be exact, Nandrolone is the AAS with the highest MA index. Since the MA index not affecte by the additional fat chain, NPP is also the highest.

What is MA?

MA is Myotrophic androgenic or anabolic-androgenic

The origin of MA is also based on Nandrolone From 1950 to 1960, the androgen activity and myogenic activity of testosterone and other AAS were the subject of a lot of research at that time. Shortly after the synthesis of nolone, Eisenberg and Gordon developed a method to index and characterize the MA activity of various exogenous AAS. Since then, AAS has its corresponding MA index.

The establishment of MA index was calculated based on the weight difference of levator ani muscle and seminal vesicle between rats and control group. Testosterone is the basis of all AAS, and its MA index is set to 1, that is, the ratio of testosterone myogenic activity to androgen activity is 1:1. The MA index determination of other AAS is based on testosterone.

The MA index of Nandrolone is 11, that is, the ratio of myogenic activity to androgen activity of Nandrolone is 11:1. Among them, its myogenic activity is 3.29-4.92 times that of testosterone, and its androgenic activity is 0.31-0.41 times that of testosterone. Therefore, the anabolism of Nandrolone is doubled compared with testosterone, and the androgen effect is lower than testosterone. The MA index of Nandrolone is the highest in AAS.

What is the importance of MA index?

Since 1935, many testosterone derivatives have been synthesized. Testosterone and its derivatives are collectively referred to as AAS, of which testosterone is a typical AAS

AAS is a synthetic anabolic androgen steroid. First, AAS is a hormone. It is easy to see what kind of hormone AAS is. Anabolic activity and androgen activity are the key parameters of AAS. Therefore, by understanding the MA index, we can know what kind of AAS this is and whether I should choose this AAS

Compared with its parent testosterone, AAS has more anabolism and less androgen. This is intentional. The higher anabolic activity is the higher myogenic activity, which can improve performance, speed up metabolism, increase muscle and maintain muscle quality. Lower androgen sex will bring less androgen side effects.

Through the MA index of NPP , we can know the role of NPP .

Nandrolone phenylpropionate steroid NPP benefits

Nandrolone phenylpropionate steroid is highly anabolic and suitable for rapid muscle growth.

A large number of experiments have proved that Norton has a significant myogenic effect.

In a trial in 2011, Nandrolone was injected into the supraspinatus tendon of rabbits. 10 were injected intramuscularly and the other 10 were kept as controls. The researchers then examined their supraspinatus muscle contractions and evaluated the amount of fat infiltration observed after 6 weeks. Compared with the control group, the supraspinatus muscle contraction and fat infiltration of the group receiving intramuscular injection of Nandrolone decreased, and muscle function increased under standardized contraction.

In 2015, the researchers used 18 high goats to do subsequent experiments. Six sheep were given 150 mg of Nandrolone once a week from the time of tendon release, and the other six sheep were given the same dose of norolone at the time of tendon repair. Six sheep after electrification served as controls. The study found that weekly injection of Nandrolone immediately after tendon release can almost completely prevent fat infiltration in the next 22 weeks, while maintaining lean muscle mass. Even if the drug was delayed 16 weeks, the sheep with tendon repair could still prevent further muscle atrophy in the next 6 weeks.

The above two studies have proved the significant muscle generating effect of Nandrolone.

How dose NPP build muscle?

NPP stimulates the differentiation of myogenic progenitor cells by up regulating MyoD and Numb. In addition, it can also activate the calcineurin NFAT signal transduction that plays a role in leading to hypertrophy, thus having the role of rapid muscle growth.

NPP also increases local IGF-1 levels, leading to skeletal muscle hypertrophy. Blocking IGF-1 receptor attenuates skeletal muscle response to androgen, but does not completely prevent hypertrophy. This confirms that IGF-1 signal transduction plays an important but not independent role in androgen mediated skeletal muscle fiber hypertrophy.

NPP promotes rapid muscle growth through different modes of action. It is suitable for bodybuilder to use NPP in the building cycle

NPP dosage effect muscle gain and body weight

The effects of three doses (1mg/kg, 4mg/kg and 10mg/kg) of AAS NPP dosage on body weight and muscle protein metabolism were studied in female rats.

When NPP dosage is injected 1mg/kg NPP every day for 10 days, the body weight is significantly increased, the body protein is increased by 9%, but the body fat is not affected.

At higher doses, the influence on body weight is weakened, resulting in no change in body weight at 10mg/kg. However, the body protein content still increases by 9%, while the fat content decreases by 32%.

The body energy gain and total energy efficiency were significantly reduced in animals receiving 10 mg/kg of treatment.

The weight and protein content of gastrocnemius muscle were significantly increased in all doses of NPP injection.

The muscle protein synthesis measured in vivo was also significantly stimulated at 1 mg/kg and 4 mg/kg, but was not affected at 10 mg/kg.

These data confirm the anabolism of NPP and indicate a high dose dependence on other parameters such as body weight, fat deposition and muscle protein synthesis.

The above parameters also show that the bodybuilder can choose different NPP doses according to different purposes.

Low dose only increases muscle, and higher dose can reduce fat while increasing muscle.

How about NPP for female?

Nandrolone phenylpropionate steroid has low androgen, female bodybuilder can use it.

The male bodybuilder can choose almost all AAS, but the female bodybuilder is on the contrary. It is difficult to choose the AAS that suits her. Because the female bodybuilder is more sensitive to AAS, and is more susceptible to the side effects of androgens of AAS.

Common androgen side effects, such as deeper voice and hair growth, have no impact on men, and may even bring some additional benefits, but for women, the impact will be greater. Therefore, after women choose AAS, they usually choose a more moderate AAS. The more temperate AAS usually has lower androgen activity to avoid male side effects on female body builder. At the same time, the anabolic activity of some milder AAS is also at a moderate level, and its muscle enhancing effect is also mild.

NPP is different. It has a weak androgenic nature, which helps women avoid the side effects of masculinization. At the same time, NPP has high anabolism, which can also help women’s bodybuilder to rapidly grow muscle and consume fat.

Although female bodybuilder can use NPP , it is still used in a low dose like other AAS. The maximum NPP dosage shall not exceed 50mg per week, and the maximum period shall not exceed 6 weeks.

Why NPP side effect of hair loss and Hyperplasia of prostate is very mild?

Nandrolone phenylpropionate steroid won’t be return back to DHT by 5AR

The molecular structure of Nandrolone is basically the same as that of testosterone, except that it lacks a methyl group on C-19. The mechanism of action of Nandrolone in human body is similar to that of testosterone.

In some tissues, such as prostate or hair follicle, testosterone is converted to DHT through 5AR In prostate, 5AR activity is higher, but in skeletal muscle, 5AR activity is very low. Therefore, in skeletal muscle, testosterone directly binds to androgen receptor, which contributes to muscle growth. In prostate tissues and hair follicles, testosterone is converted into DHT by 5AR, which is known to be the cause of androgen side effects such as prostate enlargement and androgenic alopecia.

So, does not Nandrolone work with 5AR?

No, Nandrolone also works with 5AR. However, since Nandrolone is 19 nortestosterone, it generates 5 α- Dihydro-19 nortestosterone. Compared with the parent hormone testosterone, the binding affinity of this Nandrolone form reduced by 5AR to androgen is significantly reduced. Therefore, the binding ability of the Nandrolone form reduced by 5AR to the androgen receptor in the prostate is significantly reduced, resulting in a milder prostate growth.

The effect of Nandrolone on hair loss is based on the same principle. Exogenous AAS supplementation will increase the level of serum free testosterone, so more testosterone will be reduced to DHT by 5AR, and then the level of DHT in vivo will increase. DHT is the main cause of hair loss, also known as androgenic alopecia (AGA) or male alopecia AGA usually occurs in 20% of 20 year old men, and then increases by about 10% every 10 years. People with a family history of AGA hair loss are more likely to lose hair when using AAS.

However, another problem arises here – erectile dysfunction (ED).

Nandrolone phenylpropionate steroid side effect of ED

Users of finasteride have reported a certain degree of ED problems, and users of Npp have also reported a certain degree of ED problems.

What is the relationship between the two?

Finasteride prevents AAS from transforming into DHT, and 5AR will now transform Nandrolone into DHT . Research shows that DHT maintains the erectile function of the penis to a certain extent.

DHT is an active androgen in maintaining nitric oxide mediated penile erection.

After the castrate rats were treate with exogenous testosterone, their erectile function recovere. However, when testosterone and 5AR inhibitor administering together, 5AR inhibitor blocke the production of DHT, and the recovery of rats was lose.

How NPP Nandrolone phenylpropionate steroid cause ED?

Nandrolone phenylpropionate steroid is also a kind of AAS. We know that exogenous AAS supplementation can inhibit the hypothalamus pituitary gonad axis (HPGA) and endogenous testosterone level through the negative feedback loop, thereby reducing the available testosterone and DHT in the body After inhibiting endogenous testosterone level, other AAS will reduce to DHT by 5AR to maintain erectile function. However, after inhibiting endogenous testosterone level, Nandrolone will not reduce to DHT by 5AR itself, which aggravates the negative impact on erectile function.

Because it not converte into DHT, it aggravates the impact on erectile function. When stop use Nandrolone, the function will restore.

To prevent ED, bodybuilder will use NPP together with testosterone to maintain performance.Sure,tadalafil,sidenafil and vardenafil also a good choice.

Above, we focus on the differences between Npp and other AAS. There are two kinds of Nandrolone esters commonly use in Nandrolone, namely, NPP (Nandrolone phenylpropionate) and Deca (Nandrolone decanoate). So, why choose Npp among the two kinds of Nandrolone esters?

NPP vs Deca

NPP vs Deca, that is, Nandrolone phenylpropionate vs Nandrolone decanoate.The manufacturing and sales company of NPP and Deca is Organon.NPP is the abbreviation of Nandrolone dipropionate. nandrolone phenylpropionate steroid was introduce for medical use in 1959. It is the first Nandrolone ester. It is commercially sale under the brand name Durabolin.
Deca is the abbreviation of Nandrolone decanoate. Deca for medical use is in 1962. It is the second norolone ester introduce The brand name is Deca durabolin, also known as Deca by the bodybuilder.
Npp and Deca both belong to Nandrolone, and are different ester forms of Nandrolone. Esters of different lengths control the release time of Nandrolone in the body.

NPP is the short chain ester of Nandrolone, Deca is the long chain ester of Nandrolone. The shorter the ester is, the faster it takes effect. The bodybuilder can see the result faster. The longer the ester is, the slower it is release in the body and takes longer to function. It takes a long time to see the result

The half-life of NPP is about 3 days. In order to maintain the level of Nandrolone in the blood, we usually injecte it three times a week.

Deca has a half-life of about 8 days, which does not require frequent administration. We Usually injecte it once a week.

NPP vs Deca ,which should I choose?

NPP’s competitiveness is not as great as that of Nandrolone decanoate. The main reason is that Nandrolone decanoate is more convenient to buy, while NPP is more difficult to buy in the market.

After the separation of the attached ester, the hormone molecule itself will not change, because the effective ingredient of NPP and Deca is Norton. Npp and Deca provide the same benefits in terms of muscle size and strength, in addition to different half-life, and more effective recovery after exercise.

Because Deca has a longer half-life, is more convenient to use, and is also very convenient to purchase, many bodybuilders prefer to choose Deca.

However, Deca is more suitable for the selection of relatively long body building cycles, such as cycles over 12 weeks. If you only want to run a 10 week or 8 week cycle, Npp will be the right choice.

Injected NPP 3 times a week or every other day to maintain a stable level of Nandrolone and take effect faster than Deca.

At the same time, testosterone phenylpropionate, which has the same half-life as NPP , is also linke to phenylpropionate in testosterone, which is very convenient for stacking administration.

To sum up, if you are in a short cycle or looking for an AAS that can take effect quickly, you should choose NPP.

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